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protein coding gene - tim17 (SPAC3A12.16c) - TIM23 translocase complex subunit Tim17

Gene summary

Standard name
tim17
Systematic ID
SPAC3A12.16c
Product
TIM23 translocase complex subunit Tim17
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87130
ORFeome ID
06/06A04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1449927..1451374 reverse strand

Annotation

GO biological process

GO:0030150 - protein import into mitochondrial matrix

References:

GO:7770060 - TOM-TIM23-SORT-mediated protein insertion into the mitochondrial inner membrane

References:

GO cellular component

GO:0005739 - mitochondrion

References:

GO:0005744 - TIM23 mitochondrial import inner membrane translocase complex

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0008320 - transmembrane protein transporter activity

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02466Tim17Pfam
PTHR10485PANTHER
TIGR009803a0801so1tim17Tim17NCBIFAM

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:39753782 - Dbi1 is an oxidoreductase and an assembly chaperone for mitochondrial inner membrane proteins.
Badrie S et al. EMBO Rep 2025 Feb;26(4):911-928
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
GO_REF:0000033 - Annotation inferences using phylogenetic trees