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protein coding gene - cys12 (SPAC3A12.17c) - cysteine synthase-like protein Cys12

Gene summary

Standard name
cys12
Systematic ID
SPAC3A12.17c
Product
cysteine synthase-like protein Cys12
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
cys1b
UniProt ID
P87131
ORFeome ID
18/18H08
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome I: 1451843..1453356 reverse strand

Annotation

GO biological process

GO:0019344 - L-cysteine biosynthetic process

References:

GO:0019344 - L-cysteine biosynthetic process

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GO cellular component

GO:0005741 - mitochondrial outer membrane

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0004124 - cysteine synthase activity

References:

GO:0004124 - cysteine synthase activity

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Modification

MOD:00006 - N-glycosylated residue

References:

MOD:00128 - N6-pyridoxal phosphate-L-lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009101 - increased cell population growth on glycerol and galactose carbon source

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002343 - normal growth on terbinafine

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002640 - sensitive to clotrimazole

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00291PALPTrpB-like_PALPPFAM
cd01561CBS_likeCDD
PS00901CYS_SYNTHASEP-phosphate_BSPROSITE_PATTERNS
G3DSA:3.40.50.1100:FF:000096FUNFAM
SSF53686Tryptophan synthase beta subunit-like PLP-dependent enzymesTrpB-like_PALP_sfSUPERFAMILY
G3DSA:3.40.50.1100TrpB-like_PALP_sfGENE3D
PTHR10314CYSTATHIONINE BETA-SYNTHASECys_Synth/Cystath_Beta-SynthPANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:14981292 - Characterization of two genes encoding putative cysteine synthase required for cysteine biosynthesis in Schizosaccharomyces pombe.
Fujita Y et al. Biosci Biotechnol Biochem 2004 Feb;68(2):306-11
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:17482430 - Multiple fungal enzymes possess cysteine synthase activity in vitro.
Brzywczy J et al. Res Microbiol 2007 Jun;158(5):428-36
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59