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protein coding gene - tip1 (SPAC3C7.12) - CLIP170 family protein Tip1

Gene summary

Standard name
tip1
Systematic ID
SPAC3C7.12
Product
CLIP170 family protein Tip1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
noc1
UniProt ID
P79065
ORFeome ID
44/44D06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2089289..2091311 forward strand

Annotation

Comment

PBO:0036285 - localisation to cell tip microtubule-dependent

References:

Disease association

MONDO:0007103 - amyotrophic lateral sclerosis type 1

References:

MONDO:0005071 - nervous system disorder

References:

MONDO:0011879 - neuronopathy, distal hereditary motor, type 7B

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MONDO:0008201 - Perry syndrome

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MONDO:0008678 - Williams syndrome

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GO biological process

GO:0031122 - cytoplasmic microtubule organization

References:

GO:0030010 - establishment of cell polarity

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GO:0000226 - microtubule cytoskeleton organization

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GO cellular component

GO:0005938 - cell cortex

References:

GO:0051285 - cell cortex of cell tip

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GO:0051286 - cell tip

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GO:0005881 - cytoplasmic microtubule

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GO:1904511 - cytoplasmic microtubule plus-end

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GO:0005829 - cytosol

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GO:1990752 - microtubule end

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GO:1905721 - mitotic spindle astral microtubule end

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GO:1905759 - post-anaphase array microtubule

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GO:0043332 - mating projection tip

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GO molecular function

GO:0008017 - microtubule binding

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GO:0051010 - microtubule plus-end binding

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GO:0005515 - protein binding

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Miscellaneous functional group

PBO:0091364 - microtubule plus-end tracking protein

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00696 - phosphorylated residue

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0007166 - abolished protein localization to cell cortex during meiotic prophase I

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Genotypes:

FYPO:0006130 - abolished protein localization to microtubule during meiosis

References:

Genotypes:

FYPO:0004700 - bent vegetative cell

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Genotypes:

FYPO:0000899 - normal microtubule cytoskeleton organization during vegetative growth

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Genotypes:

FYPO:0007705 - normal protein localization to lateral cell cortex during glucose starvation

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Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

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Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

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Genotypes:

FYPO:0002112 - viable curved vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000240 - abnormal filament morphology

References:

Genotypes:

FYPO:0005464 - abnormal maintenance of protein location at cell tip during vegetative growth

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Genotypes:

FYPO:0003625 - abnormal microtubule cytoskeleton morphology during mitotic interphase

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Genotypes:

FYPO:0007998 - abnormal protein localization to interphase microtubule bundle

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0006083 - abnormal sporulation resulting in formation of ascus with four spores

References:

Genotypes:

FYPO:0001018 - abolished NETO

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Genotypes:

FYPO:0006502 - abolished protein localization to cell cortex of cell tip during vegetative growth

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Genotypes:

FYPO:0003329 - abolished protein localization to cell tip during mitotic interphase

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Genotypes:

FYPO:0005814 - abolished protein localization to microtubule plus-end

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0005794 - bent cell during G0 to G1 transition

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Genotypes:

FYPO:0004700 - bent vegetative cell

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Genotypes:

FYPO:0000015 - branched vegetative cell

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Genotypes:

FYPO:0007563 - cell cycle arrest in mitotic G1 phase in response to pheromone without starvation

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0005799 - decreased microtubule dwell time at cell tip

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0005798 - decreased protein localization to cell cortex of cell tip during vegetative growth

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Genotypes:

FYPO:0006637 - decreased protein localization to cell cortex of cell tip, with protein distributed in cortex

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Genotypes:

FYPO:0001586 - decreased protein localization to cell tip during vegetative growth

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Genotypes:

FYPO:0000933 - decreased protein localization to microtubule cytoskeleton during vegetative growth

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0005691 - decreased spindle pole body-led chromosome movement during mitotic interphase

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009101 - increased cell population growth on glycerol and galactose carbon source

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Genotypes:

FYPO:0004167 - increased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0009096 - increased cell population growth on xylose carbon source

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Genotypes:

FYPO:0000761 - increased conjugation frequency

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Genotypes:

FYPO:0003482 - increased punctate cytoplasmic protein localization

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Genotypes:

FYPO:0003194 - increased rate of microtubule depolymerization during vegetative growth

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0000224 - lemon-shaped cell

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Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

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Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0001366 - normal actin cytoskeleton organization

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Genotypes:

FYPO:0007810 - normal cytoplasmic microtubules during cellular response to pheromone

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0001400 - normal interphase microtubules

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Genotypes:

FYPO:0001399 - normal mitotic spindle

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Genotypes:

FYPO:0007167 - normal protein localization to cell cortex during meiotic prophase I

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Genotypes:

FYPO:0001402 - normal protein localization to cell cortex during vegetative growth

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Genotypes:

FYPO:0004731 - normal protein localization to interphase microtubule plus-end

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0006501 - premature actin fusion focus assembly

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0009032 - resistance to bortezomib

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0001884 - resistance to Calcofluor White

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009039 - resistance to potassium chloride

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0005968 - resistance to sodium chloride

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Genotypes:

FYPO:0005266 - resistance to sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000327 - resistance to trichostatin A

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0003595 - S-shaped cell

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Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

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Genotypes:

FYPO:0001097 - sensitive to amitrole

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000111 - sensitive to rapamycin

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Genotypes:

FYPO:0005889 - sensitive to sodium chloride

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Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0002701 - sensitive to torin1

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

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Genotypes:

FYPO:0009063 - sensitive to X-rays during vegetative growth

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Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

References:

Genotypes:

FYPO:0005796 - short disorganized microtubule bundle

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Genotypes:

FYPO:0005792 - T-shaped cell during G0 to G2 transition

References:

Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

References:

Genotypes:

FYPO:0000014 - tapered cell

References:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01302CAP_GLYCAP-Gly_domainPfam
PS00845CAP_GLY_1CAP-Gly_domainPROSITE patterns
PS50245CAP_GLY_2CAP-Gly_domainPROSITE profiles
SM01052CAP_GLYCAP-Gly_domainSMART
G3DSA:2.30.30.190CAP-Gly_dom_sfCATH-Gene3D
SSF74924CAP-Gly_dom_sfSUPERFAMILY
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMobiDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.
Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601
PMID:16951255 - S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner.
Grallert A et al. Genes Dev 2006 Sep 01;20(17):2421-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16624923 - Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase.
Yamashita A et al. Genetics 2006 Jul;173(3):1187-96
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:15509865 - The p150-Glued Ssm4p regulates microtubular dynamics and nuclear movement in fission yeast.
Niccoli T et al. J Cell Sci 2004 Nov 01;117(Pt 23):5543-56
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.
Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:15184402 - Regulation of a formin complex by the microtubule plus end protein tea1p.
Feierbach B et al. J Cell Biol 2004 Jun 07;165(5):697-707
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:12034771 - Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.
Behrens R et al. J Cell Biol 2002 May 27;157(5):783-93
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:36138017 - Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.
Wang X et al. Nat Commun 2022 Sep 22;13(1):5565
PMID:22144913 - Widespread cotranslational formation of protein complexes.
Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:12234926 - Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.
Hirata D et al. EMBO J 2002 Sep 16;21(18):4863-74
PMID:21336311 - Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.
Kume K et al. Nat Cell Biol 2011 Mar;13(3):234-42
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
PMID:19808886 - Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
Martín-García R et al. J Cell Sci 2009 Nov 01;122(Pt 21):3862-72
PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.
Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25691662 - Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.
Koyano T et al. Mol Cell Biol 2015 May;35(9):1533-42
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.
Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62
PMID:15809031 - Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.
Martin SG et al. Dev Cell 2005 Apr;8(4):479-91
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20498706 - Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.
Goldstone S et al. PLoS One 2010 May 13;5(5):e10634
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:15177031 - Tea2p kinesin is involved in spatial microtubule organization by transporting tip1p on microtubules.
Busch KE et al. Dev Cell 2004 Jun;6(6):831-43
PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.
Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:31071203 - The concerted actions of Tip1/CLIP-170, Klp5/Kinesin-8, and Alp14/XMAP215 regulate microtubule catastrophe at the cell end.
Niu X et al. J Mol Cell Biol 2019 Dec 23;11(11):956-966
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:31483748 - Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.
Zhurinsky J et al. Mol Biol Cell 2019 Oct 01;30(21):2695-2708
PMID:36536175 - Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends.
Maan R et al. Nat Cell Biol 2023 Jan;25(1):68-78
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:11007487 - CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast.
Brunner D et al. Cell 2000 Sep 01;102(5):695-704
PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.
Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306
PMID:12789340 - Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.
Snaith HA et al. Nature 2003 Jun 05;423(6940):647-51
PMID:16611238 - The carboxy-terminus of Alp4 alters microtubule dynamics to induce oscillatory nuclear movement led by the spindle pole body in Schizosaccharomyces pombe.
Masuda H et al. Genes Cells 2006 Apr;11(4):337-52
PMID:22608712 - The contribution of CLIP2 haploinsufficiency to the clinical manifestations of the Williams-Beuren syndrome.
Vandeweyer G et al. Am J Hum Genet 2012 Jun 08;90(6):1071-8
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:12894167 - Targeted movement of cell end factors in fission yeast.
Browning H et al. Nat Cell Biol 2003 Sep;5(9):812-8
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:15062095 - The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules.
Busch KE et al. Curr Biol 2004 Apr 06;14(7):548-59
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:9714741 - A Schizosaccharomyces pombe gene encoding a novel polypeptide with a predicted alpha-helical rod structure found in the myosin and intermediate-filament families of proteins.
Jannatipour M et al. Biochim Biophys Acta 1998 Jul 30;1399(1):67-72
PMID:15772152 - Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.
Zimmerman S et al. Mol Biol Cell 2005 Jun;16(6):2719-33
PMID:23613905 - Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants.
Höög JL et al. PLoS One 2013;8(4):e61698
PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.
Tanabe T et al. PLoS One 2019;14(4):e0214803
PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.
Abenza JF et al. PLoS One 2014;9(9):e106959
PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
Kelkar M et al. Nat Commun 2015 Oct 07;6:8445
PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Mojardín L et al. Cell Cycle 2015;14(2):206-18
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:22696680 - Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.
Al-Bassam J et al. Mol Biol Cell 2012 Aug;23(15):2878-90