protein coding gene - tip1 (SPAC3C7.12) - CLIP170 family protein Tip1
Gene summary
- Standard name
- tip1
- Systematic ID
- SPAC3C7.12
- Product
- CLIP170 family protein Tip1
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- Synonyms
- noc1
- UniProt ID
- P79065
- ORFeome ID
- 44/44D06
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome I: 2089289..2091311 forward strand
Annotation
Miscellaneous functional group
Qualitative gene expression
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF01302 | CAP_GLY | CAP-Gly_domain | PFAM |
| PS00845 | CAP_GLY_1 | CAP-Gly_domain | PROSITE_PATTERNS |
| PS50245 | CAP_GLY_2 | CAP-Gly_domain | PROSITE_PROFILES |
| SM01052 | CAP_GLY_2 | CAP-Gly_domain | SMART |
| SSF74924 | Cap-Gly domain | CAP-Gly_dom_sf | SUPERFAMILY |
| G3DSA:2.30.30.190 | | CAP-Gly_dom_sf | GENE3D |
| Coil | Coil | | COILS |
| mobidb-lite-Disorder | disorder_prediction | | MOBIDB-Disorder |
| mobidb-lite-Polar | disorder_prediction | | MOBIDB-Polar |
Orthologs
- DCTN1 (HGNC:2711) Homo sapiens
- tip1 (SJAG_02695) Schizosaccharomyces japonicus
- BIK1 (YCL029C) Saccharomyces cerevisiae
References / Literature
- PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
- Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
- PMID:16611238 - The carboxy-terminus of Alp4 alters microtubule dynamics to induce oscillatory nuclear movement led by the spindle pole body in Schizosaccharomyces pombe.
- Masuda H et al. Genes Cells 2006 Apr;11(4):337-52
- PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
- Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
- PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
- Roguev A et al. Science 2008 Oct 17;322(5900):405-10
- PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.
- Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308
- PMID:21336311 - Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.
- Kume K et al. Nat Cell Biol 2011 Mar;13(3):234-42
- PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
- Sun LL et al. PLoS Genet 2013;9(8):e1003715
- PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
- Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
- PMID:15062095 - The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules.
- Busch KE et al. Curr Biol 2004 Apr 06;14(7):548-59
- PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
- Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
- PMID:12894167 - Targeted movement of cell end factors in fission yeast.
- Browning H et al. Nat Cell Biol 2003 Sep;5(9):812-8
- PMID:15509865 - The p150-Glued Ssm4p regulates microtubular dynamics and nuclear movement in fission yeast.
- Niccoli T et al. J Cell Sci 2004 Nov 01;117(Pt 23):5543-56
- PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.
- Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62
- PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
- Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
- PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
- Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
- PMID:15184402 - Regulation of a formin complex by the microtubule plus end protein tea1p.
- Feierbach B et al. J Cell Biol 2004 Jun 07;165(5):697-707
- PMID:15809031 - Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.
- Martin SG et al. Dev Cell 2005 Apr;8(4):479-91
- PMID:18257517 - Phosphoproteome analysis of fission yeast.
- Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
- PMID:31483748 - Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.
- Zhurinsky J et al. Mol Biol Cell 2019 Oct 01;30(21):2695-2708
- PMID:36138017 - Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.
- Wang X et al. Nat Commun 2022 Sep 22;13(1):5565
- PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.
- Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81
- PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
- Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
- PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
- Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
- Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
- PMID:22696680 - Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.
- Al-Bassam J et al. Mol Biol Cell 2012 Aug;23(15):2878-90
- PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
- Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
- PMID:23613905 - Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants.
- Höög JL et al. PLoS One 2013;8(4):e61698
- PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.
- Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601
- PMID:12234926 - Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.
- Hirata D et al. EMBO J 2002 Sep 16;21(18):4863-74
- PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
- Mojardín L et al. Cell Cycle 2015;14(2):206-18
- PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
- Kelkar M et al. Nat Commun 2015 Oct 07;6:8445
- PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.
- Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306
- PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
- Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
- Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
- PMID:22608712 - The contribution of CLIP2 haploinsufficiency to the clinical manifestations of the Williams-Beuren syndrome.
- Vandeweyer G et al. Am J Hum Genet 2012 Jun 08;90(6):1071-8
- PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
- Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
- PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.
- Abenza JF et al. PLoS One 2014;9(9):e106959
- PMID:25691662 - Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.
- Koyano T et al. Mol Cell Biol 2015 May;35(9):1533-42
- PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
- Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
- PMID:12789340 - Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.
- Snaith HA et al. Nature 2003 Jun 05;423(6940):647-51
- PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
- Blyth J et al. Genetics 2018 Feb;208(2):589-603
- PMID:11007487 - CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast.
- Brunner D et al. Cell 2000 Sep 01;102(5):695-704
- PMID:16951255 - S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner.
- Grallert A et al. Genes Dev 2006 Sep 01;20(17):2421-36
- PMID:22144913 - Widespread cotranslational formation of protein complexes.
- Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398
- PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
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- PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.
- Tanabe T et al. PLoS One 2019;14(4):e0214803
- PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
- Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
- PMID:15177031 - Tea2p kinesin is involved in spatial microtubule organization by transporting tip1p on microtubules.
- Busch KE et al. Dev Cell 2004 Jun;6(6):831-43
- PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
- Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
- PMID:36536175 - Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends.
- Maan R et al. Nat Cell Biol 2023 Jan;25(1):68-78
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:12034771 - Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.
- Behrens R et al. J Cell Biol 2002 May 27;157(5):783-93
- PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
- Das J et al. Sci Signal 2013 May 21;6(276):ra38
- PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
- Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
- PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
- Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
- PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
- Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
- PMID:9714741 - A Schizosaccharomyces pombe gene encoding a novel polypeptide with a predicted alpha-helical rod structure found in the myosin and intermediate-filament families of proteins.
- Jannatipour M et al. Biochim Biophys Acta 1998 Jul 30;1399(1):67-72
- PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
- Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
- PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.
- Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
- Halova L et al. Open Biol 2021 Apr;11(4):200405
- PMID:19808886 - Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
- Martín-García R et al. J Cell Sci 2009 Nov 01;122(Pt 21):3862-72
- PMID:16624923 - Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase.
- Yamashita A et al. Genetics 2006 Jul;173(3):1187-96
- PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
- Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
- PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
- Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
- PMID:15772152 - Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.
- Zimmerman S et al. Mol Biol Cell 2005 Jun;16(6):2719-33
- PMID:31071203 - The concerted actions of Tip1/CLIP-170, Klp5/Kinesin-8, and Alp14/XMAP215 regulate microtubule catastrophe at the cell end.
- Niu X et al. J Mol Cell Biol 2019 Dec 23;11(11):956-966
- PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
- Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
- PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
- Rodríguez-López M et al. Elife 2023 Oct 03;12
- PMID:20498706 - Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.
- Goldstone S et al. PLoS One 2010 May 13;5(5):e10634
