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protein coding gene - grs1 (SPAC3F10.03) - mitochondrial and cytoplasmic glycine-tRNA ligase Grs1

Gene summary

Standard name
grs1
Systematic ID
SPAC3F10.03
Product
mitochondrial and cytoplasmic glycine-tRNA ligase Grs1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10179
ORFeome ID
27/27A09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2821360..2823619 forward strand

Annotation

Complementation

PBO:0016536 - functionally complements S. cerevisiae YBR121C

References:

PBO:0016537 - functionally complements S. cerevisiae YPR081C

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Disease association

MONDO:0015626 - Charcot-Marie-Tooth disease

References:

MONDO:0011091 - Charcot-Marie-Tooth disease type 2D

References:

MONDO:0005071 - nervous system disorder

References:

MONDO:0015353 - neuronopathy, distal hereditary motor, type 5A

References:

MONDO:0033621 - spinal muscular atrophy, infantile, James type

References:

GO biological process

GO:0002181 - cytoplasmic translation

References:

GO:0015966 - diadenosine tetraphosphate biosynthetic process

References:

GO:0070150 - mitochondrial glycyl-tRNA aminoacylation

References:

GO:0032543 - mitochondrial translation

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

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GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0141192 - ATP:ATP adenylyltransferase activity

References:

GO:0004820 - glycine-tRNA ligase activity

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

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MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03129HGTP_anticodonAnticodon-bdPfam
cd00774GlyRS-like_coreGlyRS-like_coreCDD
cd00858GlyRS_anticodonCDD
PS50862AA_TRNA_LIGASE_IIaa-tRNA-synth_IIPROSITE profiles
PR01043TRNASYNTHGLYPRINTS
G3DSA:3.30.40.230:FF:000002CATH-FunFam
G3DSA:3.30.720.200:FF:000001CATH-FunFam
G3DSA:3.30.930.10:FF:000010CATH-FunFam
G3DSA:3.30.930.10:FF:000158CATH-FunFam
G3DSA:3.40.50.800:FF:000004CATH-FunFam
G3DSA:3.30.40.230CATH-Gene3D
G3DSA:3.30.720.200CATH-Gene3D
G3DSA:3.30.930.10aa-tRNA-synth_II/BPL/LPLCATH-Gene3D
G3DSA:3.40.50.800Anticodon-bd_dom_sfCATH-Gene3D
SSF52954SUPERFAMILY
SSF55681aa-tRNA-synth_II/BPL/LPLSUPERFAMILY
PTHR10745Gly-tRNA_synthase/POLG2PANTHER
NF003211PRK04173.1NCBIFAM
TIGR00389glyS_dimerictRNA-synt_glyNCBIFAM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:10874035 - One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions.
Turner RJ et al. J Biol Chem 2000 Sep 08;275(36):27681-8
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23293578 - Molecular genetics of charcot-marie-tooth disease: from genes to genomes.
Azzedine H et al. Mol Syndromol 2012 Nov;3(5):204-14
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000051 - S. pombe keyword mapping
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87