protein coding gene - gsa1 (SPAC3F10.04) - glutathione synthetase large and small subunit Gsa1

Gene summary

Standard name

gsa1

Systematic ID

SPAC3F10.04

Product

glutathione synthetase large and small subunit Gsa1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

gsh2

UniProt ID

P35669

ORFeome ID

24/24C01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2823730..2827612 forward strand

Annotation

Protein features

Orthologs

• GSS (HGNC:4624) Homo sapiens
• gsa1 (SJAG_01351) Schizosaccharomyces japonicus
• GSH2 (YOL049W) Saccharomyces cerevisiae

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:1958212 - Cloning and sequencing of the gene encoding the large subunit of glutathione synthetase of Schizosaccharomyces pombe.

Mutoh N et al. Biochem Biophys Res Commun 1991 Nov 27;181(1):430-6

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:19180638 - SpOPT1, a member of the oligopeptide family (OPT) of the fission yeast Schizosaccharomyces pombe, is involved in the transport of glutathione through the outer membrane of the cell.

Dworeck T et al. Yeast 2009 Jan;26(1):67-73

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:15529002 - Transcriptional regulation of glutathione synthetase in the fission yeast Schizosaccharomyces pombe.

Kim SJ et al. Mol Cells 2004 Oct 31;18(2):242-8

PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493

PMID:9017391 - apd1+, a gene required for red pigment formation in ade6 mutants of Schizosaccharomyces pombe, encodes an enzyme required for glutathione biosynthesis: a role for glutathione and a glutathione-conjugate pump.

Chaudhuri B et al. Genetics 1997 Jan;145(1):75-83

PMID:9291132 - Glutathione synthetase: similarities of the proteins from Schizosaccharomyces pombe and Arabidopsis thaliana.

Wang CL et al. Biochem J 1997 Sep 01;326 ( Pt 2)(Pt 2):563-6

PMID:2894829 - Isolation of mutants of Schizosaccharomyces pombe unable to synthesize cadystin, small cadmium-binding peptides.

Mutoh N et al. Biochem Biophys Res Commun 1988 Feb 29;151(1):32-9

PMID:8660701 - A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends.

Shi ZZ et al. Arch Biochem Biophys 1996 Jul 15;331(2):215-24

PMID:12787490 - Regulation of the gene encoding glutathione synthetase from the fission yeast.

Kim SJ et al. J Biochem Mol Biol 2003 May 31;36(3):326-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:8192897 - Glutathione synthetase from the fission yeast. Purification and its unique heteromeric subunit structure.

Nakagawa CW et al. Biochem Cell Biol 1993;71(9-10):447-53

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:10219997 - Biosynthesis of phytochelatins in the fission yeast. Phytochelatin synthesis: a second role for the glutathione synthetase gene of Schizosaccharomyces pombe.

Al-Lahham A et al. Yeast 1999 Mar 30;15(5):385-96

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:8914526 - Cloning of the cDNA and genomic clones for glutathione synthetase from Arabidopsis thaliana and complementation of a gsh2 mutant in fission yeast.

Wang CL et al. Plant Mol Biol 1996 Sep;31(6):1093-104

PMID:12734194 - The glutathione synthetase of Schizosaccharomyces pombe is synthesized as a homodimer but retains full activity when present as a heterotetramer.

Phlippen N et al. J Biol Chem 2003 Oct 10;278(41):40152-61

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PB_REF:0000003 - Disease Association Curation

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55