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protein coding gene - erf4 (SPAC3F10.07c) - palmitoyltransferase complex accessory subunit Erf4

Gene summary

Standard name
erf4
Systematic ID
SPAC3F10.07c
Product
palmitoyltransferase complex accessory subunit Erf4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug91
UniProt ID
Q10182
ORFeome ID
05/05B06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2828666..2829184 reverse strand

Annotation

Disease association

MONDO:0018874 - acute myeloid leukemia

References:

GO biological process

GO:0006612 - protein targeting to membrane

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0031211 - endoplasmic reticulum palmitoyltransferase complex

References:

GO:0005794 - Golgi apparatus

References:

Genome organisation

PBO:0001757 - co-expressed with adjacent gene

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002511 - abolished protein palmitoylation during meiosis

References:

Genotypes:

FYPO:0002507 - abolished protein palmitoylation during vegetative growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002502 - normal protein palmitoylation during vegetative growth

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000199 - previously annotated as dubious

PBO:0001756 - protein coding overlap with adjacent gene

Protein features

IDNameInterPro nameDB name
PF10256Erf4Golgin_A_7/ERF4Pfam
PTHR13254Ras_palmitoyltransferasePANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.
Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.
Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597
PMID:36650056 - Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe .
Pham TV et al. Life Sci Alliance 2023 Apr;6(4)
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.
Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83