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protein coding gene - map3 (SPAC3F10.10c) - pheromone M-factor receptor Map3

Gene summary

Standard name
map3
Systematic ID
SPAC3F10.10c
Product
pheromone M-factor receptor Map3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P31397
ORFeome ID
17/17B12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2833231..2834988 reverse strand

Annotation

GO biological process

GO:0007186 - G protein-coupled receptor signaling pathway

References:

GO:0062038 - positive regulation of pheromone response MAPK cascade

References:

GO cellular component

GO:0005886 - plasma membrane

References:

GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

References:

GO:0036319 - mating-type M-factor pheromone receptor activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0006503 - abnormal protein localization to actin fusion focus

References:

Genotypes:

FYPO:0006505 - abolished protein localization to shmoo tip

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0001219 - increased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0000573 - normal shmoo formation

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Genotypes:

FYPO:0006500 - premature cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

Protein sequence feature

SO:0001809 - signal_anchor

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000995 - abnormal cell morphology during nitrogen starvation

References:

Genotypes:

FYPO:0006503 - abnormal protein localization to actin fusion focus

References:

Genotypes:

FYPO:0000302 - abnormal response to pheromone

References:

Genotypes:

FYPO:0005791 - abnormal shmoo directionality

References:

Genotypes:

FYPO:0006505 - abolished protein localization to shmoo tip

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0000822 - decreased concentration of P-factor in growth medium

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0004174 - h+ specific sterility

References:

Genotypes:

FYPO:0004565 - increased transcription of pheromone response gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0004084 - normal protein level during nitrogen starvation

References:

Genotypes:

FYPO:0000590 - normal sporulation

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0001756 - protein coding overlap with adjacent gene

Protein features

IDNameInterPro nameDB name
PF02076STE3GPCR_STE3PFAM
cd149667tmD_STE3CDD
PR00899GPCRSTE3GPCR_STE3PRINTS
PTHR28097PHEROMONE A FACTOR RECEPTORGPCR_STE3PANTHER

Orthologs

References / Literature

GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:25831518 - Molecular coevolution of a sex pheromone and its receptor triggers reproductive isolation in Schizosaccharomyces pombe.
Seike T et al. Proc Natl Acad Sci U S A 2015 Apr 07;112(14):4405-10
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.
Egel R et al. Yeast 1994 Oct;10(10):1347-54
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.
Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23200991 - Cdc42 explores the cell periphery for mate selection in fission yeast.
Bendezú FO et al. Curr Biol 2013 Jan 07;23(1):42-7
PMID:8807800 - Autocrine response of Schizosaccharomyces pombe haploid cells to mating pheromones.
Kitamura K et al. FEMS Microbiol Lett 1996 Sep 15;143(1):41-5
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.
Aono T et al. Yeast 1994 Jun;10(6):757-70
PMID:8380233 - Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.
Tanaka K et al. Mol Cell Biol 1993 Jan;13(1):80-8
PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.
Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:15300681 - Characterization of end4+, a gene required for endocytosis in Schizosaccharomyces pombe.
Iwaki T et al. Yeast 2004 Jul 30;21(10):867-81
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:27798845 - Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion.
Dudin O et al. Genes Dev 2016 Oct 01;30(19):2226-2239
PMID:25252312 - [Ash2, a subunit of histone H3K4 methyltransferase complex, is involved in the sporulation in Schizosaccharomyces pombe].
Wang W et al. Yi Chuan 2014 Sep;36(9):943-51
PMID:9003326 - The Schizosaccharomyces pombe map1 gene encodes an SRF/MCM1-related protein required for P-cell specific gene expression.
Nielsen O et al. Mol Gen Genet 1996 Dec 13;253(3):387-92