PomBase home

protein coding gene - hrp3 (SPAC3G6.01) - CHD family chromatin remodeller Hrp3

Gene summary

Standard name
hrp3
Systematic ID
SPAC3G6.01
Product
CHD family chromatin remodeller Hrp3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14139
ORFeome ID
30/30G04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5377824..5382913 forward strand

Annotation

Comment

PBO:0001406 - overlapping genome wide occupancy in coding regions Nap1/Hrp1/Hrp3

References:

PBO:0001407 - overlapping genome wide occupancy in promoters Nap1/Hrp1/Hrp3

References:

PBO:0001405 - targets correlated with Clr3 and Sir2 targets

References:

Disease association

MONDO:0014150 - developmental and epileptic encephalopathy 94

References:

MONDO:0060568 - Pilarowski-Bjornsson syndrome

References:

GO biological process

GO:0006338 - chromatin remodeling

References:

GO:0045815 - transcription initiation-coupled chromatin remodeling

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0140658 - ATP-dependent chromatin remodeler activity

References:

GO:0003677 - DNA binding

References:

GO:0042393 - histone binding

References:

GO:0031491 - nucleosome binding

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01149 - sumoylated lysine

References:

Multi-locus phenotype

FYPO:0000854 - abnormal nucleosome positioning in euchromatin

References:

Genotypes:

FYPO:0006358 - abolished chromatin remodeling during glucose starvation

References:

Genotypes:

FYPO:0002879 - abolished transcription during glucose starvation

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004491 - decreased nucleosome occupancy

References:

Genotypes:

FYPO:0006754 - decreased promoter-enhancer looping during glucose starvation

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0003557 - increased antisense RNA level

References:

Genotypes:

FYPO:0002913 - increased antisense RNA transcription

References:

Genotypes:

FYPO:0005522 - increased forward centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0005518 - increased histone H3-K14 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0004347 - increased histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0005523 - increased reverse centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0000284 - large and small daughter nuclei, with unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

References:

Genotypes:

FYPO:0003224 - normal histone H3-K14 acetylation during vegetative growth

References:

Genotypes:

FYPO:0003223 - normal histone H3-K9 acetylation during vegetative growth

References:

Genotypes:

FYPO:0005336 - normal level of histone H3 in cell

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002546 - sensitive to trichostatin A

References:

Genotypes:

Protein features

PBO:0111831 - chromodomain protein

PBO:0111747 - DEAD/DEAH box helicase

PBO:0111748 - helicase C-terminal domain

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005521 - abnormal nucleosome organization

References:

Genotypes:

FYPO:0004988 - abnormal RNA level oscillation during mitotic cell cycle

References:

Genotypes:

FYPO:0005520 - abolished nucleosome-dependent ATPase activity

References:

Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0006357 - decreased chromatin remodeling during glucose starvation

References:

Genotypes:

FYPO:0000890 - decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0004227 - decreased nucleosome binding

References:

Genotypes:

FYPO:0004491 - decreased nucleosome occupancy

References:

Genotypes:

FYPO:0005524 - decreased nucleosome occupancy at centromere central core

References:

Genotypes:

FYPO:0005525 - decreased nucleosome occupancy at centromere inner repeat

References:

Genotypes:

FYPO:0005516 - decreased nucleosome occupancy in euchromatin

References:

Genotypes:

FYPO:0007722 - decreased nucleosome-dependent ATPase activity

References:

Genotypes:

FYPO:0003120 - decreased transcription during glucose starvation

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0003557 - increased antisense RNA level

References:

Genotypes:

FYPO:0002913 - increased antisense RNA transcription

References:

Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0005518 - increased histone H3-K14 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0004347 - increased histone H3-K9 acetylation at protein coding gene during vegetative growth

References:

Genotypes:

FYPO:0007656 - increased nucleosome occupancy at transcription start site

References:

Genotypes:

FYPO:0001974 - increased number of cells with 1C DNA content

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0002837 - normal centromeric outer repeat transcript-derived siRNA level

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0000980 - normal growth on amphotericin B

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002620 - normal growth on trichostatin A

References:

Genotypes:

FYPO:0004743 - normal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0002390 - normal mitotic sister chromatid cohesion

References:

Genotypes:

FYPO:0005949 - normal protein localization to chromatin at highly transcribed RNA polymerase II genes during vegetative growth

References:

Genotypes:

FYPO:0002389 - normal protein localization to heterochromatin at centromere outer repeat

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009039 - resistance to potassium chloride

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0000084 - sensitive to 6-azauracil

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002641 - sensitive to micafungin

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00271Helicase_CHelicase_C-likePFAM
PF23588HTH_CHD1_Hrp3CHD1-2/Hrp3_HTHPFAM
PF13907CHD1-like_CCHD1-like_CPFAM
PF18196Cdh1_DBD_1Cdh1_DBDPFAM
PF00385ChromoChromo_domainPFAM
PF00176SNF2-rel_domSNF2_NPFAM
cd18793SF2_C_SNFSNF2/RAD54-like_CCDD
cd17993DEXHc_CHD1_2CDD
cd18665CD1_tandem_CHD1_yeast_likeCDD
cd18659CD2_tandemCDD
PS00598CHROMO_1Chromodomain_CSPROSITE_PATTERNS
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE_PROFILES
PS50013CHROMO_2Chromo/chromo_shadow_domPROSITE_PROFILES
PS51194HELICASE_CTERHelicase_C-likePROSITE_PROFILES
SM00490helicmild6Helicase_C-likeSMART
SM00487ultradead3Helicase_ATP-bdSMART
SM00298chromo_7Chromo/chromo_shadow_domSMART
SM01176DUF4208_2CHD1-like_CSMART
G3DSA:1.10.10.60:FF:000376FUNFAM
G3DSA:3.40.50.300:FF:000130FUNFAM
G3DSA:3.40.50.10810:FF:000007FUNFAM
G3DSA:2.40.50.40:FF:000038FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF54160Chromo domain-likeChromo-like_dom_sfSUPERFAMILY
G3DSA:6.10.140.1440GENE3D
G3DSA:3.40.50.10810SNF2-like_sfGENE3D
G3DSA:1.10.10.60GENE3D
G3DSA:2.40.50.40GENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR45623CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATEDPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:33468217 - Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
Weigt M et al. Epigenetics Chromatin 2021 Jan 19;14(1):8
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15908586 - The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres.
Walfridsson J et al. Nucleic Acids Res 2005;33(9):2868-79
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:32277274 - Conserved roles of chromatin remodellers in cohesin loading onto chromatin.
Muñoz S et al. Curr Genet 2020 Oct;66(5):951-956
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23103765 - CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe.
Pointner J et al. EMBO J 2012 Nov 28;31(23):4388-403
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:12127990 - Hrp3, a chromodomain helicase/ATPase DNA binding protein, is required for heterochromatin silencing in fission yeast.
Jae Yoo E et al. Biochem Biophys Res Commun 2002 Jul 26;295(4):970-4
PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:28934464 - Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.
Asada R et al. Nucleic Acids Res 2017 Sep 19;45(16):9361-9371
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.
Zhou X et al. PLoS One 2013;8(5):e65904
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:22990236 - Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.
Shim YS et al. EMBO J 2012 Nov 28;31(23):4375-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:25122751 - Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription.
García P et al. Nucleic Acids Res 2014;42(16):10351-9
PMID:17510629 - A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly.
Walfridsson J et al. EMBO J 2007 Jun 20;26(12):2868-79
PMID:39096900 - Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance.
Sahu RK et al. Mol Cell 2024 Sep 05;84(17):3175-3191.e8
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25602522 - The impact of the HIRA histone chaperone upon global nucleosome architecture.
Gal C et al. Cell Cycle 2015;14(1):123-34
GO_REF:0000002 - Comments
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:23032292 - Chd1 chromatin remodelers maintain nucleosome organization and repress cryptic transcription.
Hennig BP et al. EMBO Rep 2012 Nov 06;13(11):997-1003
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:36509793 - Functional crosstalk between the cohesin loader and chromatin remodelers.
Muñoz S et al. Nat Commun 2022 Dec 13;13(1):7698
PMID:37956308 - Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery.
Vega M et al. Nucleic Acids Res 2023 Dec 11;51(22):12161-12173
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:18199689 - Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26.
Hirota K et al. Mol Biol Cell 2008 Mar;19(3):1162-73
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:28674280 - Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1.
Adachi A et al. Genes Genet Syst 2018 May 03;92(6):267-276
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:33670267 - The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.
Dong W et al. Int J Mol Sci 2021 Feb 11;22(4)
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:28143796 - Clr4 specificity and catalytic activity beyond H3K9 methylation.
Kusevic D et al. Biochimie 2017 Apr;135:83-88
PMID:32496538 - Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.
Sansó M et al. Nucleic Acids Res 2020 Jul 27;48(13):7154-7168