protein coding gene - erv1 (SPAC3G6.08) - mitochondrial Mia40-Erv1 disulfide relay system sulfhydryl oxidase subunit Erv1

Gene summary

Standard name: erv1
Systematic ID: SPAC3G6.08
Product: mitochondrial Mia40-Erv1 disulfide relay system sulfhydryl oxidase subunit Erv1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14144
ORFeome ID: 05/05F04
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 5393579..5394534 forward strand

Annotation

Disease association

MONDO:0013116 - congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome

References:

GO biological process

GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

References:

GO_REF:0000024

GO:0160203 - protein import into the intermembrane space via the disulfide relay system

References:

GO_REF:0000024

GO cellular component

GO:0005758 - mitochondrial intermembrane space

References:

GO_REF:0000024

GO molecular function

GO:0016971 - flavin-dependent sulfhydryl oxidase activity

References:

GO_REF:0000024

Modification

MOD:00689 - disulfide crosslinked residues

References:

PMID:36408920

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

erv1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

erv1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF04777	Evr1_Alr	ERV/ALR_sulphydryl_oxidase	Pfam
PS51324	ERV_ALR	ERV/ALR_sulphydryl_oxidase	PROSITE profiles
G3DSA:1.20.120.310		ERV/ALR_sulphydryl_oxid_sf	CATH-Gene3D
G3DSA:4.10.320.60			CATH-Gene3D
SSF69000		ERV/ALR_sulphydryl_oxid_sf	SUPERFAMILY
PTHR12645		ALR/ERV	PANTHER

Orthologs

GFER (HGNC:4236) Homo sapiens
erv1 (SJAG_01647) Schizosaccharomyces japonicus
ERV1 (YGR029W) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24866464 - Mitochondrial protein translocases for survival and wellbeing.: Sokol AM et al. FEBS Lett 2014 Aug 01;588(15):2484-95
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623