protein coding gene - tif211 (SPAC3G9.09c) - translation initiation factor eIF2 alpha subunit

Gene summary

Standard name

tif211

Systematic ID

SPAC3G9.09c

Product

translation initiation factor eIF2 alpha subunit

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

eIF2alpha

UniProt ID

P56286

ORFeome ID

17/17A04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3166428..3167699 forward strand

Annotation

Protein features

Orthologs

• EIF2S1 (HGNC:3265) Homo sapiens
• tif211 (SJAG_03629) Schizosaccharomyces japonicus
• SUI2 (YJR007W) Saccharomyces cerevisiae

References / Literature

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86

PMID:31285271 - Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis.

Wang YT et al. Mol Cell Biol 2019 Oct 01;39(19)

PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Zhang K et al. Science 2011 Mar 25;331(6024):1624-7

PMID:26901872 - Crystal structure of eukaryotic translation initiation factor 2B.

Kashiwagi K et al. Nature 2016 Mar 03;531(7592):122-5

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23671279 - Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.

Tarumoto Y et al. J Biol Chem 2013 Jun 28;288(26):19260-8

PMID:30072440 - Regulation of global translation during the cell cycle.

Stonyte V et al. J Cell Sci 2018 Sep 03;131(17)

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:19880757 - Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.

Berlanga JJ et al. Eukaryot Cell 2010 Jan;9(1):194-207

PMID:16278445 - Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast.

Dunand-Sauthier I et al. Eukaryot Cell 2005 Nov;4(11):1785-93

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:19033384 - The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint.

Krohn M et al. J Cell Sci 2008 Dec 15;121(Pt 24):4047-54

PMID:20547592 - Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.

Wen WL et al. Nucleic Acids Res 2010 Oct;38(19):6555-66

PMID:21098141 - Cellular stress induces cytoplasmic RNA granules in fission yeast.

Nilsson D et al. RNA 2011 Jan;17(1):120-33

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22172946 - The stress granule protein Vgl1 and poly(A)-binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe.

Morita T et al. Biochem Biophys Res Commun 2012 Jan 06;417(1):399-403

PMID:27627185 - Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.

Kashiwagi K et al. FEBS J 2017 Mar;284(6):868-874

PMID:17369398 - A novel checkpoint mechanism regulating the G1/S transition.

Tvegård T et al. Genes Dev 2007 Mar 15;21(6):649-54

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:28771613 - Activation of Gcn2 in response to different stresses.

Anda S et al. PLoS One 2017;12(8):e0182143

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:25639242 - Nitrogen regulates AMPK to control TORC1 signaling.

Davie E et al. Curr Biol 2015 Feb 16;25(4):445-54

PMID:26493332 - Stress-induced inhibition of translation independently of eIF2α phosphorylation.

Knutsen JH et al. J Cell Sci 2015 Dec 01;128(23):4420-7

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:23687372 - New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.

Martín R et al. J Cell Sci 2013 Jul 15;126(Pt 14):3010-20

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

PMID:31048492 - Structural basis for eIF2B inhibition in integrated stress response.

Kashiwagi K et al. Science 2019 May 03;364(6439):495-499

PMID:33534698 - Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.

Fukuda T et al. Elife 2021 Feb 03;10

PMID:24818994 - The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Jongjitwimol J et al. PLoS One 2014;9(5):e94182

PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .

Budden AM et al. Elife 2023 Aug 24;12

PMID:12242291 - Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.

Zhan K et al. Mol Cell Biol 2002 Oct;22(20):7134-46

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:33970532 - Magnesium depletion extends fission yeast lifespan via general amino acid control activation.

Ohtsuka H et al. Microbiologyopen 2021 Mar;10(2):e1176