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protein coding gene - msw1 (SPAC3G9.13c) - mitochondrial tryptophan-tRNA ligase Msw1

Gene summary

Standard name
msw1
Systematic ID
SPAC3G9.13c
Product
mitochondrial tryptophan-tRNA ligase Msw1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O42875
ORFeome ID
23/23E04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3150170..3156856 forward strand

Annotation

Disease association

MONDO:0060578 - neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures

References:

MONDO:0030676 - parkinsonism-dystonia 3, childhood-onset

References:

GO biological process

GO:0070183 - mitochondrial tryptophanyl-tRNA aminoacylation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004830 - tryptophan-tRNA ligase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00579tRNA-synt_1baa-tRNA-synth_IcPFAM
cd00806TrpRS_coreTrp-tRNA-ligaseCDD
PS00178AA_TRNA_LIGASE_Iaa-tRNA-synth_I_CSPROSITE_PATTERNS
PR01039TRNASYNTHTRPTrp-tRNA-ligasePRINTS
G3DSA:3.40.50.620:FF:000144FUNFAM
G3DSA:1.10.240.10:FF:000002FUNFAM
SSF52374Nucleotidylyl transferaseSUPERFAMILY
G3DSA:3.40.50.620HUPsRossmann-like_a/b/a_foldGENE3D
G3DSA:1.10.240.10GENE3D
PTHR43766TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIALTrp-tRNA_synthetasePANTHER
MF_00140_BTrp_tRNA_synth_BTrp-tRNA-ligase_bac-typeHAMAP
TIGR00233trpSTrp-tRNA-ligaseNCBIFAM

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623