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protein coding gene - orc3 (SPAC3H1.01c) - origin recognition complex subunit Orc3

Gene summary

Standard name
orc3
Systematic ID
SPAC3H1.01c
Product
origin recognition complex subunit Orc3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
orp3, SPAP14E8.06c
UniProt ID
Q10067
ORFeome ID
37/37D04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1928771..1931303 reverse strand

Annotation

GO biological process

GO:0006270 - DNA replication initiation

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0031261 - DNA replication preinitiation complex

References:

GO:0005664 - nuclear origin of replication recognition complex

References:

GO:0005656 - nuclear pre-replicative complex

References:

GO:0043596 - nuclear replication fork

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GO molecular function

GO:0003688 - DNA replication origin binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002273 - inviable vegetative cell with abnormal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07034ORC3_NORC3_NPfam
PF18137WHD_ORCORC_WH_CPfam
cd20704Orc3CDD
PTHR12748ORC3PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:10535928 - Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe.
Moon KY et al. Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12367-72
PMID:11689699 - Site-specific DNA binding of the Schizosaccharomyces pombe origin recognition complex is determined by the Orc4 subunit.
Kong D et al. Mol Cell Biol 2001 Dec;21(23):8095-103
PMID:18723846 - Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions.
Houchens CR et al. J Biol Chem 2008 Oct 31;283(44):30216-24
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:11850415 - Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.
Chuang RY et al. J Biol Chem 2002 May 10;277(19):16920-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:11717425 - The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein.
Lee JK et al. Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13589-94
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87