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protein coding gene - sdd3 (SPAC3H1.02c) - mitochondrial matrix protease Sdd3

Gene summary

Standard name
sdd3
Systematic ID
SPAC3H1.02c
Product
mitochondrial matrix protease Sdd3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ppp54
UniProt ID
Q10068
ORFeome ID
30/30A09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1931489..1934884 reverse strand

Annotation

Disease association

MONDO:0030318 - spinocerebellar ataxia, autosomal recessive 30

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GO biological process

GO:0035694 - mitochondrial protein catabolic process

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GO cellular component

GO:0005759 - mitochondrial matrix

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GO molecular function

GO:0046872 - metal ion binding

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GO:0004222 - metalloendopeptidase activity

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Modification

MOD:00047 - O-phospho-L-threonine

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00675Peptidase_M16Pept_M16_NPfam
PF05193Peptidase_M16_CPeptidase_M16_CPfam
G3DSA:3.30.830.10:FF:000015CATH-FunFam
G3DSA:3.30.830.10:FF:000031CATH-FunFam
G3DSA:3.30.830.10CATH-Gene3D
SSF63411Metalloenz_LuxS/M16SUPERFAMILY
PTHR43016PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
PANTHER:PTHR43016:SF3 - Unknown title
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16849325 - Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP.
Falkevall A et al. J Biol Chem 2006 Sep 29;281(39):29096-104