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protein coding gene - pol1 (SPAC3H5.06c) - DNA polymerase alpha catalytic subunit

Gene summary

Standard name
pol1
Systematic ID
SPAC3H5.06c
Product
DNA polymerase alpha catalytic subunit
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
swi7, polA
UniProt ID
P28040
ORFeome ID
49/49H03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3430955..3436241 forward strand

Annotation

Comment

PBO:0017717 - pol1 promoter region contains 5 near matches to the MluI cell cycle box (MCB) consensus sequence

References:

Complementation

PBO:0002048 - functionally complemented by S. cerevisiae YNL102W

References:

Disease association

MONDO:0010686 - N syndrome

References:

MONDO:0015601 - X-linked intellectual disability, van Esch type

References:

MONDO:0010523 - X-linked reticulate pigmentary disorder

References:

GO biological process

GO:0006281 - DNA repair

References:

GO:0000731 - DNA synthesis involved in DNA repair

References:

GO:0007534 - gene conversion at mating-type locus

References:

GO:0006273 - lagging strand elongation

References:

GO:0006272 - leading strand elongation

References:

GO:1902975 - mitotic DNA replication initiation

References:

GO:1902315 - nuclear cell cycle DNA replication initiation

References:

GO:0033260 - nuclear DNA replication

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GO cellular component

GO:0005658 - alpha DNA polymerase:primase complex

References:

GO:0000785 - chromatin

References:

GO:0140445 - chromosome, telomeric repeat region

References:

GO:0005634 - nucleus

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0003682 - chromatin binding

References:

GO:0003688 - DNA replication origin binding

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GO:0003887 - DNA-directed DNA polymerase activity

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GO:0005515 - protein binding

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GO:0003697 - single-stranded DNA binding

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GO:0008270 - zinc ion binding

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0000611 - abnormal cell cycle arrest in mitotic S phase

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0004254 - abnormal mitotic cell cycle regulation during cellular response to UV

References:

Genotypes:

FYPO:0000062 - abnormal nuclear morphology during vegetative growth

References:

Genotypes:

FYPO:0006728 - abolished mitotic DNA replication initiation

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Genotypes:

FYPO:0005095 - abolished protein localization to chromatin at replication origin

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Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0002577 - decreased chromatin binding

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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Genotypes:

FYPO:0006731 - decreased CMG complex progression from replication origin

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Genotypes:

FYPO:0006729 - decreased protein localization to chromatin distal to replication origin

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

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Genotypes:

FYPO:0000614 - increased duration of mitotic S phase

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Genotypes:

FYPO:0004961 - increased protein localization to chromatin at replication origin

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

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Genotypes:

FYPO:0000951 - inviable small vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001387 - loss of viability at high temperature

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Genotypes:

FYPO:0000256 - mutator

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Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

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Genotypes:

FYPO:0001428 - normal negative regulation of mitotic DNA replication initiation

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Genotypes:

FYPO:0001380 - normal nuclear morphology during vegetative growth

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Genotypes:

FYPO:0003076 - normal protein autophosphorylation during vegetative growth

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Genotypes:

FYPO:0004962 - normal protein localization to chromatin at replication origin

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Genotypes:

FYPO:0004378 - normal protein localization to heterochromatin at silent mating-type cassette

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Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein sequence feature

SO:0001528 - nuclear_localization_signal

References:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

References:

PomGeneEx:0000020 - protein level unchanged

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PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000013 - RNA level unchanged

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000611 - abnormal cell cycle arrest in mitotic S phase

References:

Genotypes:

FYPO:0000468 - abnormal mating type switching

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0001933 - abnormal mitotic cell cycle regulation during cellular response to hydroxyurea

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Genotypes:

FYPO:0000338 - abnormal mitotic spindle

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Genotypes:

FYPO:0000062 - abnormal nuclear morphology during vegetative growth

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Genotypes:

FYPO:0006436 - abnormal S-phase DNA damage checkpoint during cellular response to methyl methanesulfonate

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Genotypes:

FYPO:0007598 - abolished chromatin silencing at ectopic tethering site

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Genotypes:

FYPO:0000469 - abolished mating type switching

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Genotypes:

FYPO:0000474 - abolished meiosis

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Genotypes:

FYPO:0002044 - abolished premeiotic DNA replication

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Genotypes:

FYPO:0002779 - abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0006438 - alkylation damage repair intermediates absent

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0003217 - decreased chromatin silencing at centromere central core

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Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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Genotypes:

FYPO:0008454 - decreased chromatin silencing at ectopic tethering site

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Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

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Genotypes:

FYPO:0003352 - decreased DNA double-strand break formation at mating-type locus

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Genotypes:

FYPO:0007158 - decreased histone H3 binding

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Genotypes:

FYPO:0007159 - decreased histone H4 binding

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0002097 - decreased protein kinase activity during cellular response to hydroxyurea

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0004313 - decreased protein localization to CENP-A containing chromatin

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Genotypes:

FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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Genotypes:

FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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Genotypes:

FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0002624 - decreased punctate nuclear protein localization

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Genotypes:

FYPO:0004322 - decreased spatial extent of CENP-A containing chromatin assembly

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Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0007599 - increased chromatin silencing at ectopic tethering site

References:

Genotypes:

FYPO:0000614 - increased duration of mitotic S phase

References:

Genotypes:

FYPO:0005788 - increased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0007314 - increased histone H4-K12 acetylation at centromere central core during vegetative growth

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Genotypes:

FYPO:0004324 - increased histone H4-K16 acetylation at centromere central core during vegetative growth

References:

Genotypes:

FYPO:0007312 - increased histone H4-K5 acetylation at centromere central core during vegetative growth

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Genotypes:

FYPO:0007313 - increased histone H4-K8 acetylation at centromere central core during vegetative growth

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Genotypes:

FYPO:0001742 - increased isochromosome formation

References:

Genotypes:

FYPO:0006439 - increased level of X-shaped replication intermediates

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Genotypes:

FYPO:0000473 - increased mitotic recombination

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Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0003077 - increased protein autophosphorylation during vegetative growth

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Genotypes:

FYPO:0002700 - increased protein kinase activity

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Genotypes:

FYPO:0002541 - increased protein localization to nucleoplasm

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Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0005031 - increased ribonucleotide incorporation on lagging strand

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Genotypes:

FYPO:0002985 - increased RNA level during cellular response to methyl methanesulfonate

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0004493 - inviable after spore germination, single cell division, small cell

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Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

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Genotypes:

FYPO:0003760 - inviable after spore germination, single or double cell division, arrest with cut

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Genotypes:

FYPO:0003784 - inviable after spore germination, single or double cell division, arrest with septated mononucleate cell

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Genotypes:

FYPO:0004113 - inviable after spore germination, without cell division, small cell

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

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Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

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Genotypes:

FYPO:0001497 - inviable elongated cell with mitotic cell cycle arrest in interphase

References:

Genotypes:

FYPO:0003128 - inviable elongated mononucleate aseptate cell with cell cycle arrest in mitotic M phase

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Genotypes:

FYPO:0002904 - inviable pear-shaped vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0003166 - monoseptate vegetative cell with binucleate and anucleate compartments

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Genotypes:

FYPO:0000256 - mutator

References:

Genotypes:

FYPO:0003086 - normal chromatin binding

References:

Genotypes:

FYPO:0007425 - normal gene conversion

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

References:

Genotypes:

FYPO:0008272 - normal histone H3 binding

References:

Genotypes:

FYPO:0008273 - normal histone H4 binding

References:

Genotypes:

FYPO:0006437 - normal mitotic DNA damage checkpoint during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0001399 - normal mitotic spindle

References:

Genotypes:

FYPO:0001380 - normal nuclear morphology during vegetative growth

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12254DNA_pol_alpha_NDNA_pol_a_cat_su_NPFAM
PF08996zf-DNA_PolZnf_DNA-dir_DNA_pol_B_alphaPFAM
PF03104DNA_pol_B_exo1DNA-dir_DNA_pol_B_exonucPFAM
PF00136DNA_pol_BDNA-dir_DNA_pol_B_multi_domPFAM
cd05532POLBc_alphaPOLBc_alphaCDD
cd05776DNA_polB_alpha_exoCDD
PS00116DNA_POLYMERASE_BDNA-dir_DNA_pol_B_CSPROSITE_PATTERNS
SM00486polmehr3DNA-dir_DNA_pol_BSMART
PR00106DNAPOLBDNA-dir_DNA_pol_BPRINTS
G3DSA:1.10.132.60:FF:000004FUNFAM
G3DSA:3.30.70.2820:FF:000001FUNFAM
G3DSA:3.30.420.10:FF:000036FUNFAM
G3DSA:1.10.287.690:FF:000003FUNFAM
SSF53098Ribonuclease H-likeRNaseH-like_sfSUPERFAMILY
SSF56672DNA/RNA polymerasesDNA/RNA_pol_sfSUPERFAMILY
G3DSA:3.90.1600.10Palm domain of DNA polymeraseDNA_pol_palm_dom_sfGENE3D
G3DSA:1.10.3200.20DNA Polymerase alpha, zinc fingerPol_alpha_znc_sfGENE3D
G3DSA:3.30.420.10RNaseH_sfGENE3D
G3DSA:3.30.70.2820GENE3D
G3DSA:1.10.132.60DNA_pol_B_thumbGENE3D
G3DSA:2.40.50.730GENE3D
PTHR45861DNA POLYMERASE ALPHA CATALYTIC SUBUNITPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
TIGR00592pol2NCBIFAM

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:12455694 - mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.
Williams DR et al. Eukaryot Cell 2002 Oct;1(5):758-73
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:15643072 - Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.
Williams DR et al. Eukaryot Cell 2005 Jan;4(1):166-77
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:9154809 - A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.
Uchiyama M et al. Mol Cell Biol 1997 Jun;17(6):3103-15
PMID:15915339 - Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.
Tsutsui Y et al. Curr Genet 2005 Jul;48(1):34-43
PMID:10588642 - Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Pasion SG et al. Mol Biol Cell 1999 Dec;10(12):4043-57
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:19205745 - Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.
Yasuhira S Mol Genet Genomics 2009 May;281(5):497-509
PMID:33568651 - Replication dynamics of recombination-dependent replication forks.
Naiman K et al. Nat Commun 2021 Feb 10;12(1):923
PMID:14766746 - Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p.
Fien K et al. J Biol Chem 2004 Apr 16;279(16):16144-53
PMID:19214192 - Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
Moser BA et al. EMBO J 2009 Apr 08;28(7):810-20
PMID:11581276 - Chromodomain protein Swi6-mediated role of DNA polymerase alpha in establishment of silencing in fission Yeast.
Ahmed S et al. J Biol Chem 2001 Dec 21;276(51):47814-21
PMID:23322785 - The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.
Santosa V et al. J Biol Chem 2013 Mar 08;288(10):6864-80
PMID:15579205 - Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27.
Gray FC et al. BMC Mol Biol 2004 Dec 03;5(1):21
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22718908 - DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.
Handa T et al. Mol Biol Cell 2012 Aug;23(16):3240-53
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:12514100 - Checkpoint activation regulates mutagenic translesion synthesis.
Kai M et al. Genes Dev 2003 Jan 01;17(1):64-76
PMID:26436826 - Polymerase δ replicates both strands after homologous recombination-dependent fork restart.
Miyabe I et al. Nat Struct Mol Biol 2015 Nov;22(11):932-8
PMID:6587363 - Genes required for initiation and resolution steps of mating-type switching in fission yeast.
Egel R et al. Proc Natl Acad Sci U S A 1984 Jun;81(11):3481-5
PMID:9693370 - Mutational effect of fission yeast polalpha on cell cycle events.
Bhaumik D et al. Mol Biol Cell 1998 Aug;9(8):2107-23
PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.
McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238
PMID:9356477 - Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint.
D'Urso G et al. Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12491-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25691662 - Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.
Koyano T et al. Mol Cell Biol 2015 May;35(9):1533-42
PMID:17209013 - Role of SUMO in the dynamics of telomere maintenance in fission yeast.
Xhemalce B et al. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):893-8
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23071723 - DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
Koulintchenko M et al. PLoS One 2012;7(10):e47091
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11073977 - Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.
Boddy MN et al. Mol Cell Biol 2000 Dec;20(23):8758-66
PMID:10559981 - A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins.
Edwards RJ et al. Nat Cell Biol 1999 Nov;1(7):393-8
PMID:14739927 - Regulation of checkpoint kinases through dynamic interaction with Crb2.
Mochida S et al. EMBO J 2004 Jan 28;23(2):418-28
PMID:24719968 - Switching genes in Schizosaccharomyces pombe.
Gutz H et al. Curr Genet 1985;9(5):325-31
PMID:8319772 - In vivo phosphorylation, mitotic behavior, and nuclear binding of the catalytic subunit of DNA polymerase alpha in fission yeast.
Bouvier D et al. Exp Cell Res 1993 Jul;207(1):41-7
PMID:11313455 - Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures.
Kai M et al. Mol Cell Biol 2001 May;21(10):3289-301
PMID:8367300 - Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype.
Francesconi S et al. Nucleic Acids Res 1993 Aug 11;21(16):3821-8
PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.
Matmati S et al. Sci Adv 2018 May;4(5):eaar2740
PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.
Snaith HA et al. Genetics 1999 Jul;152(3):839-51
PMID:36138017 - Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.
Wang X et al. Nat Commun 2022 Sep 22;13(1):5565
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:9135148 - p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.
Francesconi S et al. EMBO J 1997 Mar 17;16(6):1332-41
PMID:9710635 - A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast.
Singh J et al. Mol Cell Biol 1998 Sep;18(9):5511-22
GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
PB_REF:0000003 - Disease Association Curation
PMID:8537450 - DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast.
D'Urso G et al. J Cell Sci 1995 Sep;108 ( Pt 9):3109-18
PMID:18615848 - Role of heterochromatin in suppressing subtelomeric recombination in fission yeast.
Bisht KK et al. Yeast 2008 Aug;25(8):537-48
PMID:9407031 - Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.
Saka Y et al. Genes Dev 1997 Dec 15;11(24):3387-400
PMID:10716938 - Fission yeast switches mating type by a replication-recombination coupled process.
Arcangioli B et al. EMBO J 2000 Mar 15;19(6):1389-96
PMID:12697806 - Replication proteins influence the maintenance of telomere length and telomerase protein stability.
Dahlén M et al. Mol Cell Biol 2003 May;23(9):3031-42
PMID:9891047 - Mutator phenotype induced by aberrant replication.
Liu VF et al. Mol Cell Biol 1999 Feb;19(2):1126-35
PMID:18493607 - A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.
Natsume T et al. PLoS One 2008 May 21;3(5):e2221
PMID:8423854 - DNA polymerase-alpha is essential for mating-type switching in fission yeast.
Singh J et al. Nature 1993 Jan 21;361(6409):271-3
PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.
Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:19109429 - GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.
Pai CC et al. Mol Biol Cell 2009 Feb;20(4):1213-22
PMID:8443413 - Cell cycle expression of two replicative DNA polymerases alpha and delta from Schizosaccharomyces pombe.
Park H et al. Mol Biol Cell 1993 Feb;4(2):145-57
PMID:25822347 - Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.
Khan S et al. PLoS One 2015;10(3):e0124063
PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82
PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.
Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24
PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.
Gómez EB et al. Genetics 2008 Jun;179(2):757-71
PMID:26041456 - RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
Audry J et al. EMBO J 2015 Jul 14;34(14):1942-58
PMID:7723827 - A kinase from fission yeast responsible for blocking mitosis in S phase.
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PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.
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