protein coding gene - spo20 (SPAC3H8.10) - sec14 cytosolic factor family, phospholipid-intermembrane transfer protein Spo20/Sec14

Gene summary

Standard name

spo20

Systematic ID

SPAC3H8.10

Product

sec14 cytosolic factor family, phospholipid-intermembrane transfer protein Spo20/Sec14

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sec14

UniProt ID

Q10137

ORFeome ID

18/18E01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 608969..610703 forward strand

Annotation

Protein features

Orthologs

• SEC14L1 (HGNC:10698) Homo sapiens
• SEC14L2 (HGNC:10699) Homo sapiens
• SEC14L3 (HGNC:18655) Homo sapiens
• SEC14L4 (HGNC:20627) Homo sapiens
• SEC14L5 (HGNC:29032) Homo sapiens
• spo20 (SJAG_03746) Schizosaccharomyces japonicus
• YKL091C Saccharomyces cerevisiae
• SEC14 (YMR079W) Saccharomyces cerevisiae

References / Literature

PMID:20870879 - Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.

Dodgson J et al. Eukaryot Cell 2010 Nov;9(11):1788-97

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:16980382 - Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeast.

Ma Y et al. Genetics 2006 Nov;174(3):1259-71

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:39110593 - VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis.

Hoh KL et al. Cell Rep 2024 Aug 05;43(8):114592

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:11294895 - The Schizosaccharomyces pombe spo20(+) gene encoding a homologue of Saccharomyces cerevisiae Sec14 plays an important role in forespore membrane formation.

Nakase Y et al. Mol Biol Cell 2001 Apr;12(4):901-17

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.

Kishida M et al. Curr Genet 1986;10(6):443-7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:15569158 - The Sec14 family glycerophospholipid-transfer protein is required for structural integrity of the spindle pole body during meiosis in fission yeast.

Nakase Y et al. Genes Cells 2004 Dec;9(12):1275-86

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20519959 - S. pombe genome deletion project: an update.

Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16762840 - Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.

Zofall M et al. Mol Cell 2006 Jun 09;22(5):681-92

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.

Hirata A et al. Arch Microbiol 1992;158(4):249-55

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6