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protein coding gene - tel2 (SPAC458.03) - TTT co-chaperone complex LRR repeat subunit Tel2

Gene summary

Standard name
tel2
Systematic ID
SPAC458.03
Product
TTT co-chaperone complex LRR repeat subunit Tel2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P3W5
ORFeome ID
38/38F04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4734821..4737598 forward strand

Annotation

Complementation

PBO:0091569 - is not functionally complemented by human TELO2

References:

Disease association

MONDO:0014848 - TELO2-related intellectual disability-neurodevelopmental disorder

References:

GO biological process

GO:0051083 - 'de novo' cotranslational protein folding

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0110078 - TTT Hsp90 cochaperone complex

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GO:0005634 - nucleus

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GO molecular function

GO:0051879 - Hsp90 protein binding

References:

GO:0030674 - protein-macromolecule adaptor activity

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GO:0042162 - telomeric repeat DNA binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

Protein features

PBO:0111865 - leucine-rich repeat protein

Qualitative gene expression

PomGeneEx:0000016 - RNA level constant

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PomGeneEx:0000013 - RNA level unchanged

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000611 - abnormal cell cycle arrest in mitotic S phase

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Genotypes:

FYPO:0008117 - abnormal de novo SAGA complex assembly

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Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

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Genotypes:

FYPO:0003814 - abolished response to S-phase DNA damage checkpoint signaling

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Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0002097 - decreased protein kinase activity during cellular response to hydroxyurea

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0003803 - decreased protein localization to telomere

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Genotypes:

FYPO:0002098 - decreased protein phosphorylation during cellular response to hydroxyurea

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0004372 - decreased response to mitotic G2 DNA damage checkpoint signaling

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Genotypes:

FYPO:0003827 - decreased ribosomal S6 protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000158 - DNA content increased during vegetative growth

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Genotypes:

FYPO:0001974 - increased number of cells with 1C DNA content

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Genotypes:

FYPO:0000455 - increased number of double-strand break sites during vegetative growth

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Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0002095 - increased protein phosphorylation during cellular response to DNA damage

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Genotypes:

FYPO:0002096 - increased protein phosphorylation during cellular response to hydroxyurea

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Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

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Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

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Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

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Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

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Genotypes:

FYPO:0001690 - normal growth on camptothecin

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Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0002672 - normal growth on rapamycin

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0002357 - normal protein-RNA interaction

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0004720 - normal viability following cellular response to heat shock

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Genotypes:

FYPO:0004795 - normal zygotic meiosis

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10193Telomere_reg-2Telomere_length_regulation_domPFAM
PF25320TELO2_ARMTELO2_ARMPFAM
G3DSA:1.25.40.720TEL2_C_sfGENE3D
PTHR15830TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBERTEL2_RegulationPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte

Orthologs

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.
Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:17189249 - Tel2 is required for activation of the Mrc1-mediated replication checkpoint.
Shikata M et al. J Biol Chem 2007 Feb 23;282(8):5346-55
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20801936 - Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Takai H et al. Genes Dev 2010 Sep 15;24(18):2019-30
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.
Inoue H et al. Genes Cells 2017 Jan;22(1):59-70
PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.
Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs