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protein coding gene - dli1 (SPAC458.04c) - meiotic dynein intermediate light chain Dli1/Dil1

Gene summary

Standard name
dli1
Systematic ID
SPAC458.04c
Product
meiotic dynein intermediate light chain Dli1/Dil1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
dil1
UniProt ID
Q9P3W4
ORFeome ID
43/43G08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4737481..4738897 reverse strand

Annotation

GO biological process

GO:0030989 - dynein-driven meiotic oscillatory nuclear movement

References:

GO:0000226 - microtubule cytoskeleton organization

References:

GO:0000743 - nuclear migration involved in conjugation with cellular fusion

References:

GO cellular component

GO:0005938 - cell cortex

References:

GO:0030981 - cortical microtubule cytoskeleton

References:

GO:1903754 - cortical microtubule plus-end

References:

GO:0005737 - cytoplasm

References:

GO:0005868 - cytoplasmic dynein complex

References:

GO:0005829 - cytosol

References:

GO:0035974 - meiotic spindle pole body

References:

GO:0015630 - microtubule cytoskeleton

References:

GO:0110092 - nucleus leading edge

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GO molecular function

GO:0045504 - dynein heavy chain binding

References:

Modification

MOD:00394 - monoacetylated residue

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Multi-locus phenotype

FYPO:0007989 - abolished nuclear congression during mating

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000015 - RNA absent

References:

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000197 - abnormal horsetail movement

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0000913 - abnormal sporulation resulting in formation of ascus containing non-uniform spores

References:

Genotypes:

FYPO:0000927 - abolished horsetail movement

References:

Genotypes:

FYPO:0007999 - abolished protein localization to spindle pole body during karyogamy

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0000933 - decreased protein localization to microtubule cytoskeleton during vegetative growth

References:

Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0000513 - delayed onset of nuclear fusion during mating

References:

Genotypes:

FYPO:0002091 - lagging meiotic chromosomes

References:

Genotypes:

FYPO:0002094 - normal meiotic sister chromatid cohesion

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

References:

Genotypes:

FYPO:0000925 - unequal meiotic chromosome segregation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PTHR12688DYNEIN LIGHT INTERMEDIATE CHAINDynein1_light_intermed_chainPANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.
Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50
PMID:25736293 - Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe.
Fujita I et al. J Cell Sci 2015 Apr 15;128(8):1555-67
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:10366596 - A cytoplasmic dynein heavy chain is required for oscillatory nuclear movement of meiotic prophase and efficient meiotic recombination in fission yeast.
Yamamoto A et al. J Cell Biol 1999 Jun 14;145(6):1233-49
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:20298435 - Contribution of dynein light intermediate and intermediate chains to subcellular localization of the dynein-dynactin motor complex in Schizosaccharomyces pombe.
Fujita I et al. Genes Cells 2010 Apr 01;15(4):359-72
PMID:25869666 - Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.
Scheffler K et al. J Cell Biol 2015 Apr 13;209(1):47-58
PMID:20404563 - High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.
Rumpf C et al. Cell Cycle 2010 May;9(9):1802-8
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8