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protein coding gene - ptc4 (SPAC4A8.03c) - mitochondrial serine/threonine protein phosphatase PP2C catalytic subunit Ptc4

Gene summary

Standard name
ptc4
Systematic ID
SPAC4A8.03c
Product
mitochondrial serine/threonine protein phosphatase PP2C catalytic subunit Ptc4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14156
ORFeome ID
18/18B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2540745..2542655 reverse strand

Annotation

Disease association

MONDO:0017052 - intermediate maple syrup urine disease

References:

MONDO:0014057 - maple syrup urine disease, mild variant

References:

GO biological process

GO:0034599 - cellular response to oxidative stress

References:

GO:1903753 - negative regulation of p38MAPK cascade

References:

GO:1901098 - positive regulation of autophagosome maturation

References:

GO:0061191 - positive regulation of vacuole fusion, non-autophagic

References:

GO:1903715 - regulation of aerobic respiration

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0000329 - fungal-type vacuole membrane

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GO:0005759 - mitochondrial matrix

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GO molecular function

GO:0043169 - cation binding

References:

GO:0033549 - MAP kinase phosphatase activity

References:

GO:0004722 - protein serine/threonine phosphatase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0004333 - increased protein phosphorylation during cellular response to hydrogen peroxide

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000710 - abnormal mitotic cell cycle arrest in response to nitrogen starvation

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Genotypes:

FYPO:0004338 - abolished cell population growth on ethanol carbon source

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Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

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Genotypes:

FYPO:0000562 - abolished cellular respiration

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Genotypes:

FYPO:0004337 - abolished protein localization to mitochondrion

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Genotypes:

FYPO:0004335 - abolished protein-protein interaction during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0009100 - decreased cell population growth on glycerol and galactose carbon source

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0000342 - decreased cellular respiration

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

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Genotypes:

FYPO:0004339 - decreased protein localization to nucleus during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0001422 - decreased protein processing during vegetative growth

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Genotypes:

FYPO:0004341 - delayed onset of mitochondrial fission during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0002723 - increased cellular pigment accumulation during cellular response to cadmium ion

References:

Genotypes:

FYPO:0004334 - increased protein localization to nucleus during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0004333 - increased protein phosphorylation during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002795 - large vacuoles present in decreased numbers during vegetative growth

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0001409 - normal growth on glycerol carbon source

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

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Genotypes:

FYPO:0004327 - normal protein phosphorylation during cellular response to sorbitol

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Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

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Genotypes:

FYPO:0001112 - premature cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0009032 - resistance to bortezomib

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Genotypes:

FYPO:0002634 - resistance to cobalt

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0000327 - resistance to trichostatin A

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002792 - small vacuoles present in increased numbers during cellular hypotonic response

References:

Genotypes:

FYPO:0002791 - small vacuoles present in increased numbers during stationary phase

References:

Genotypes:

FYPO:0000281 - small vacuoles present in increased numbers during vegetative growth

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00481PP2CPPM-type_phosphatase-like_domPFAM
cd00143PP2CcPPM-type_phosphatase-like_domCDD
PS01032PPM_1PP2C_BSPROSITE_PATTERNS
PS51746PPM_2PPM-type_phosphatase-like_domPROSITE_PROFILES
SM00332PP2C_4PPM-type_phosphatase-like_domSMART
G3DSA:3.60.40.10:FF:000112FUNFAM
SSF81606PP2C-likePPM-type-like_dom_sfSUPERFAMILY
G3DSA:3.60.40.10PPM-type-like_dom_sfGENE3D
PTHR13832PROTEIN PHOSPHATASE 2CPP2CPANTHER

Orthologs

References / Literature

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:22139357 - H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.
Di Y et al. EMBO J 2012 Feb 01;31(3):563-75
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
GO_REF:0000002 - Comments
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:25639242 - Nitrogen regulates AMPK to control TORC1 signaling.
Davie E et al. Curr Biol 2015 Feb 16;25(4):445-54
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28377506 - Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.
Singh A et al. J Biol Chem 2017 Jun 02;292(22):9088-9103
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:10436019 - Vacuole fusion regulated by protein phosphatase 2C in fission yeast.
Gaits F et al. Mol Biol Cell 1999 Aug;10(8):2647-54
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000003 - Disease Association Curation
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623