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protein coding gene - sds22 (SPAC4A8.12c) - serine/threonine protein phosphatase PP1 regulatory subunit Sds22

Gene summary

Standard name
sds22
Systematic ID
SPAC4A8.12c
Product
serine/threonine protein phosphatase PP1 regulatory subunit Sds22
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P22194
ORFeome ID
49/49A05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2573160..2574541 reverse strand

Annotation

GO biological process

GO:0045842 - positive regulation of mitotic metaphase/anaphase transition

References:

GO:1901970 - positive regulation of mitotic sister chromatid separation

References:

GO:0023052 - signaling

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0072357 - PTW/PP1 phosphatase complex

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GO molecular function

GO:0072542 - protein phosphatase activator activity

References:

GO:0019888 - protein phosphatase regulator activity

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Modification

MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein features

PBO:0111865 - leucine-rich repeat protein

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

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Genotypes:

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

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Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000214 - abnormal mitotic chromosome condensation

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Genotypes:

FYPO:0000670 - abnormal mitotic sister chromatid separation

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Genotypes:

FYPO:0001424 - abolished protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0002700 - increased protein kinase activity

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Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

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Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0007664 - mononucleate monoseptate vegetative cell with anucleate compartment

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF14580LRR_9PFAM
PF12799LRR_4Leu-rich_rpt_4PFAM
PS51450LRRLeu-rich_rptPROSITE_PROFILES
SM00369LRR_typ_2Leu-rich_rpt_typical-subtypSMART
SM00446LRRcap_2U2A'_phosphoprotein32A_CSMART
SM00365LRR_sd22_2SMART
PR00019LEURICHRPTPRINTS
G3DSA:3.80.10.10:FF:000961FUNFAM
G3DSA:3.80.10.10:FF:001078FUNFAM
SSF52058L domain-likeSUPERFAMILY
G3DSA:3.80.10.10Ribonuclease InhibitorLRR_dom_sfGENE3D
PTHR45973PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATEDCilia_flagella_integrityPANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000051 - S. pombe keyword mapping
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15335873 - Mitotic regulation of protein phosphatases by the fission yeast sds22 protein.
Stone EM et al. Curr Biol 1993 Jan;3(1):13-26
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:1846086 - S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1.
Ohkura H et al. Cell 1991 Jan 11;64(1):149-57
PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.
Kinoshita N et al. Mol Cell Biol 1991 Dec;11(12):5839-47
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.
Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:8978689 - Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.
Ishii K et al. EMBO J 1996 Dec 02;15(23):6629-40