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protein coding gene - pts1 (SPAC4A8.13c) - 20S proteasome complex subunit beta 5

Gene summary

Standard name
pts1
Systematic ID
SPAC4A8.13c
Product
20S proteasome complex subunit beta 5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P30655
ORFeome ID
41/41F07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2574746..2575949 reverse strand

Annotation

Disease association

MONDO:0054698 - proteasome-associated autoinflammatory syndrome 1

References:

GO biological process

GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005635 - nuclear envelope

References:

GO:0005634 - nucleus

References:

GO:0019774 - proteasome core complex, beta-subunit complex

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GO molecular function

GO:0004298 - threonine-type endopeptidase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003865 - decreased protein level during G0

References:

Genotypes:

FYPO:0003872 - increased glutathione level during G0

References:

Genotypes:

FYPO:0002951 - increased L-ergothioneine level during G0

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

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Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00227ProteasomeProteasome_sua/bPFAM
cd03761proteasome_beta_type_5CDD
PS00854PROTEASOME_BETA_1Proteasome_bsu_CSPROSITE_PATTERNS
PS51476PROTEASOME_BETA_2Proteasome_suB-typePROSITE_PROFILES
PR00141PROTEASOMEPept_T1A_subBPRINTS
G3DSA:3.60.20.10:FF:000013FUNFAM
SSF56235N-terminal nucleophile aminohydrolases (Ntn hydrolases)Ntn_hydrolases_NSUPERFAMILY
G3DSA:3.60.20.10Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1Ntn_hydrolases_NGENE3D
PTHR32194METALLOPROTEASE TLDDProteasome_suB-typePANTHER

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
GO_REF:0000002 - Comments
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22173095 - Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome.
Alvarez-Castelao B et al. Biochim Biophys Acta 2012 Feb;1823(2):524-33
PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.
Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24710126 - The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.
Kitagawa T et al. Nat Commun 2014 Apr 07;5:3597
PMID:21098295 - Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.
Bohn S et al. Proc Natl Acad Sci U S A 2010 Dec 07;107(49):20992-7
PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.
Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24938783 - Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.
Leitner A et al. Proc Natl Acad Sci U S A 2014 Jul 01;111(26):9455-60
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623