protein coding gene - cdc3 (SPAC4A8.15c) - profilin

Gene summary

Standard name

cdc3

Systematic ID

SPAC4A8.15c

Product

profilin

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P39825

ORFeome ID

41/41C06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2578956..2579525 reverse strand

Annotation

Protein features

Orthologs

• PFN4 (HGNC:31103) Homo sapiens
• cdc3 (SJAG_04982) Schizosaccharomyces japonicus
• PFY1 (YOR122C) Saccharomyces cerevisiae

References / Literature

PMID:16772338 - The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.

Martín-García R et al. J Cell Sci 2006 Jul 01;119(Pt 13):2768-79

PMID:18793338 - Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe.

Villar-Tajadura MA et al. Mol Microbiol 2008 Nov;70(4):867-81

PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.

Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45

PMID:12214236 - Actin dynamics in the contractile ring during cytokinesis in fission yeast.

Pelham RJ et al. Nature 2002 Sep 05;419(6902):82-6

PMID:10087262 - Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.

Katayama S et al. J Cell Biol 1999 Mar 22;144(6):1173-86

PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.

Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75

PMID:8978670 - Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function.

Balasubramanian MK et al. EMBO J 1996 Dec 02;15(23):6426-37

PMID:17452625 - Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe.

Skoumpla K et al. J Cell Sci 2007 May 01;120(Pt 9):1635-45

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:11294907 - Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.

Wu JQ et al. Mol Biol Cell 2001 Apr;12(4):1061-77

PMID:19244341 - Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.

Skau CT et al. Mol Biol Cell 2009 Apr;20(8):2160-73

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Gómez-Gil E et al. Elife 2020 Sep 11;9

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:19028693 - Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.

Ezezika OC et al. J Biol Chem 2009 Jan 23;284(4):2088-97

PMID:23589458 - Insight into actin organization and function in cytokinesis from analysis of fission yeast mutants.

Subramanian D et al. Genetics 2013 Jun;194(2):435-46

PMID:9606213 - FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation.

Petersen J et al. J Cell Biol 1998 Jun 01;141(5):1217-28

PMID:16864655 - Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.

Wu JQ et al. J Cell Biol 2006 Jul 31;174(3):391-402

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:10588653 - A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast.

Morrell JL et al. Mol Biol Cell 1999 Dec;10(12):4201-15

PMID:10769212 - Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe.

Motegi F et al. J Cell Sci 2000 May;113 ( Pt 10):1813-25

PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.

Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10371213 - Identification of cold-sensitive mutations in the Schizosaccharomyces pombe actin locus.

McCollum D et al. FEBS Lett 1999 May 28;451(3):321-6

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

PMID:9200612 - tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.

Mata J et al. Cell 1997 Jun 13;89(6):939-49

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:11448769 - Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression.

Trautmann S et al. Curr Biol 2001 Jun 26;11(12):931-40

PMID:24127216 - The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.

Coffman VC et al. J Cell Biol 2013 Oct 14;203(1):101-14

PMID:8978671 - The Schizosaccharomyces pombe actin-related protein, Arp3, is a component of the cortical actin cytoskeleton and interacts with profilin.

McCollum D et al. EMBO J 1996 Dec 02;15(23):6438-46

PMID:11294914 - Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast.

Lu J et al. Mol Biol Cell 2001 Apr;12(4):1161-75

PMID:18378776 - The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.

Clifford DM et al. J Cell Biol 2008 Apr 07;181(1):79-88

PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.

Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801

PMID:8771785 - Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin.

Christensen HE et al. Plant J 1996 Aug;10(2):269-79

PMID:16085489 - The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.

Mishra M et al. Curr Biol 2005 Aug 09;15(15):1376-83

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:9105045 - cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.

Chang F et al. J Cell Biol 1997 Apr 07;137(1):169-82

PMID:10388810 - Identification and characterization of Schizosaccharomyces pombe asp1(+), a gene that interacts with mutations in the Arp2/3 complex and actin.

Feoktistova A et al. Genetics 1999 Jul;152(3):895-908

PMID:23394829 - Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Gupta S et al. Curr Biol 2013 Feb 18;23(4):333-8

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:11231572 - Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe.

Pelham RJ et al. Nat Cell Biol 2001 Mar;3(3):235-44

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.

Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24

PMID:12234926 - Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.

Hirata D et al. EMBO J 2002 Sep 16;21(18):4863-74

PMID:18305104 - Regulation and targeting of the fission yeast formin cdc12p in cytokinesis.

Yonetani A et al. Mol Biol Cell 2008 May;19(5):2208-19

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:9490631 - F-actin distribution and function during sexual differentiation in Schizosaccharomyces pombe.

Petersen J et al. J Cell Sci 1998 Apr;111 ( Pt 7):867-76

PMID:6490749 - Septum pattern in ts mutants of Schizosaccharomyces pombe defective in genes cdc3, cdc4, cdc8 and cdc12.

Streiblová E et al. J Cell Sci 1984 Jul;69:47-65

PMID:25543282 - Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.

Suarez C et al. Dev Cell 2015 Jan 12;32(1):43-53

PMID:31927482 - Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

Antoine M et al. iScience 2020 Jan 24;23(1):100809

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:18272786 - Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.

Ge W et al. Mol Biol Cell 2008 Apr;19(4):1680-92

PMID:24798735 - The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.

Wang N et al. J Cell Biol 2014 May 12;205(3):357-75

PMID:12456722 - Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.

Hou MC et al. J Cell Sci 2003 Jan 01;116(Pt 1):125-35

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:8207058 - The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis.

Balasubramanian MK et al. J Cell Biol 1994 Jun;125(6):1289-301

PMID:21148300 - Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.

Bendezú FO et al. Mol Biol Cell 2011 Jan 01;22(1):44-53

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:15647375 - The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling.

Yamashita A et al. Mol Biol Cell 2005 Mar;16(3):1378-95

PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.

Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:8834798 - Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring.

Chang F et al. J Cell Sci 1996 Jan;109 ( Pt 1):131-42

PMID:9108274 - A wat1 mutant of fission yeast is defective in cell morphology.

Kemp JT et al. Mol Gen Genet 1997 Mar 26;254(2):127-38

PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.

Nakano K et al. Genes Cells 2006 Aug;11(8):893-905

PMID:10459013 - Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.

Sparks CA et al. J Cell Biol 1999 Aug 23;146(4):777-90

PMID:10233158 - Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Rupes I et al. Mol Biol Cell 1999 May;10(5):1495-510

PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.

Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531