protein coding gene - rer2 (SPAC4D7.04c) - cis-prenyltransferase

Gene summary

Standard name: rer2
Systematic ID: SPAC4D7.04c
Product: cis-prenyltransferase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14171
ORFeome ID: 14/14H05
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 5357357..5358804 reverse strand

Annotation

Comment

PBO:0016984 - Rer2 can form a catalytically active complex with S. cerevisiae Nus1p

References:

PMID:25066056

Complementation

PBO:0016985 - co-expression of nus1 and rer2 functionally complements a triple deletion of NUS1, RER2 and SRT1 in S. cerevisiae

References:

PMID:25066056

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

PB_REF:0000003

MONDO:0044326 - developmental delay and seizures with or without movement abnormalities

References:

PB_REF:0000006

MONDO:0005066 - metabolic disease

References:

PB_REF:0000003

MONDO:0013468 - retinitis pigmentosa 59

References:

PB_REF:0000006

GO biological process

GO:0043048 - dolichyl monophosphate biosynthetic process

References:

PMID:25066056

GO:0009101 - glycoprotein biosynthetic process

References:

GO_REF:0000033

GO:0016094 - polyprenol biosynthetic process

References:

GO_REF:0000033

GO cellular component

GO:0098554 - cytoplasmic side of endoplasmic reticulum membrane

References:

GO_REF:0000111

GO:1904423 - dehydrodolichyl diphosphate synthase complex

References:

GO_REF:0000033

GO:0005811 - lipid droplet

References:

GO_REF:0000033

GO molecular function

GO:0045547 - ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity

References:

PMID:25066056

Modification

MOD:00047 - O-phospho-L-threonine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

rer2delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

rer2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rer2delta

Subunit composition

PBO:0015221 - heteromeric(2)

References:

PMID:25066056

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01255	Prenyltransf	UPP_synth-like	Pfam
cd00475	Cis_IPPS	UPP_synth-like	CDD
PS01066	UPP_SYNTHASE	UPP_synth-like_CS	PROSITE patterns
G3DSA:3.40.1180.10:FF:000002			CATH-FunFam
G3DSA:3.40.1180.10		UPP_synth-like_sf	CATH-Gene3D
SSF64005		UPP_synth-like_sf	SUPERFAMILY
PTHR10291		UPP_synth-like	PANTHER
TIGR00055	uppS	UPP_synth-like	NCBIFAM
MF_01139	ISPT	UPP_synth-like	HAMAP

Orthologs

DHDDS (HGNC:20603) Homo sapiens
rer2 (SJAG_02163) Schizosaccharomyces japonicus
RER2 (YBR002C) Saccharomyces cerevisiae
SRT1 (YMR101C) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.: Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25066056 - Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.: Park EJ et al. Cell Metab 2014 Sep 02;20(3):448-57
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PB_REF:0000003 - Disease Association Curation
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;