protein coding gene - fet5 (SPAC4D7.12c) - predicted GTPase with a role in RNA polymerase localization

Gene summary

Standard name: fet5
Systematic ID: SPAC4D7.12c
Product: predicted GTPase with a role in RNA polymerase localization
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14443
ORFeome ID: 32/32A05
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 5373996..5375035 reverse strand

Annotation

GO biological process

GO:0006606 - protein import into nucleus

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0003924 - GTPase activity

References:

GO_REF:0000033

Modification

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

fet5delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

fet5delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF03029	ATP_bind_1	Gpn	Pfam
cd17872	GPN3	Gpn3	CDD
PS52071	GPN_LOOP_GTPASE	Gpn	PROSITE profiles
G3DSA:3.40.50.300:FF:000552			CATH-FunFam
G3DSA:3.40.50.300		P-loop_NTPase	CATH-Gene3D
SSF52540		P-loop_NTPase	SUPERFAMILY
PTHR21231		Gpn	PANTHER
mobidb-lite-Disorder	disorder_prediction		MobiDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MobiDB-Polyampholyte

Orthologs

GPN3 (HGNC:30186) Homo sapiens
fet5 (SJAG_01655) Schizosaccharomyces japonicus
GPN3 (YLR243W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.: Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .: Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;