protein coding gene - atg13 (SPAC4F10.07c) - autophagy associated protein Atg13

Gene summary

Standard name

atg13

Systematic ID

SPAC4F10.07c

Product

autophagy associated protein Atg13

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

apg13, mug78

UniProt ID

O36019

ORFeome ID

38/38E11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4840485..4843603 reverse strand

Annotation

Protein features

Orthologs

• ATG13 (HGNC:29091) Homo sapiens
• atg13 (SJAG_01274) Schizosaccharomyces japonicus
• ATG13 (YPR185W) Saccharomyces cerevisiae

References / Literature

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:31941401 - Atg38-Atg8 interaction in fission yeast establishes a positive feedback loop to promote autophagy.

Yu ZQ et al. Autophagy 2020 Nov;16(11):2036-2051

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:27737912 - Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast.

Zhao D et al. J Cell Sci 2016 Nov 15;129(22):4289-4304

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:30116786 - Genetic regulation of mitotic competence in G 0 quiescent cells.

Sajiki K et al. Sci Adv 2018 Aug;4(8):eaat5685

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.

Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64

PMID:34499159 - Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif.

Morozumi Y et al. J Cell Sci 2021 Oct 01;134(19)

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:17295836 - Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.

Kohda TA et al. Genes Cells 2007 Feb;12(2):155-70

PMID:26389686 - Open and closed HORMAs regulate autophagy initiation.

Suzuki H et al. Autophagy 2015 Nov 02;11(11):2123-2124

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:33064910 - Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast.

Shimasaki T et al. Genes Cells 2020 Dec;25(12):825-830

PMID:28976798 - Conserved and unique features of the fission yeast core Atg1 complex.

Nanji T et al. Autophagy 2017;13(12):2018-2027

PMID:26030876 - Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation.

Suzuki H et al. Nat Struct Mol Biol 2015 Jul;22(7):572-80

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:26365378 - ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos.

Liu XM et al. Mol Cell 2015 Sep 17;59(6):1035-42

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:29330317 - tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.

Otsubo Y et al. EMBO Rep 2018 Mar;19(3)

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:28671615 - TORC1-Dependent Phosphorylation Targets in Fission Yeast.

Otsubo Y et al. Biomolecules 2017 Jul 03;7(3)

PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.

Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:34147496 - Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast.

Sawada N et al. J Biol Chem 2021 Jul;297(1):100891

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:34499173 - Visual detection of binary, ternary and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay.

Yu ZQ et al. J Cell Sci 2021 Oct 01;134(19)

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:19778961 - Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.

Mukaiyama H et al. Microbiology (Reading) 2009 Dec;155(Pt 12):3816-3826

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:32909946 - Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation.

Pan ZQ et al. Elife 2020 Sep 10;9

PMID:40931865 - Evolutionary diversification of the autophagy initiation complex: reduced Atg101 dependency and changes in Atg9 binding to Atg13.

Lai Z et al. Autophagy 2025 Sep 18;:1-18

PMID:41917004 - Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast.

Ma ZH et al. Nat Commun 2026 Mar 31;

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323