protein coding gene - spn1 (SPAC4F10.11) - mitotic septin Spn1

Gene summary

Standard name

spn1

Systematic ID

SPAC4F10.11

Product

mitotic septin Spn1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O36023

ORFeome ID

33/33A11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4853040..4855199 forward strand

Annotation

Protein features

Orthologs

• SEPTIN7 (HGNC:1717) Homo sapiens
• SEPTIN1 (HGNC:2879) Homo sapiens
• SEPTIN2 (HGNC:7729) Homo sapiens
• SEPTIN5 (HGNC:9164) Homo sapiens
• SEPTIN4 (HGNC:9165) Homo sapiens
• spn1 (SJAG_01277) Schizosaccharomyces japonicus
• CDC3 (YLR314C) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:25411334 - The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.

Wang N et al. Mol Biol Cell 2015 Jan 15;26(2):238-55

PMID:27385337 - Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Liu Y et al. Mol Biol Cell 2016 Aug 15;27(16):2528-41

PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.

McDonald NA et al. Elife 2017 Sep 15;6

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:23956092 - [Cnb1 involved in cytokinesis in Schizosaccharomyces pombe].

Fan JQ et al. Yi Chuan 2013 Aug;35(8):1030-9

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.

Wu JQ et al. Dev Cell 2003 Nov;5(5):723-34

PMID:25724972 - Rho4 interaction with exocyst and septins regulates cell separation in fission yeast.

Pérez P et al. Microbiology (Reading) 2015 May;161(Pt 5):948-959

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:25015293 - Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.

Lei B et al. J Cell Sci 2014 Sep 15;127(Pt 18):4024-36

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:15385632 - Requirements of fission yeast septins for complex formation, localization, and function.

An H et al. Mol Biol Cell 2004 Dec;15(12):5551-64

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24947517 - The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.

Muñoz S et al. J Biol Chem 2014 Aug 08;289(32):21995-2007

PMID:40972526 - The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain.

Warner JL et al. Mol Cell 2025 Sep 18;85(18):3407-3424.e8

PMID:20739711 - Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.

Wu JQ et al. Genetics 2010 Nov;186(3):897-915

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

GO_REF:0000002 - Comments

PMID:18272786 - Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.

Ge W et al. Mol Biol Cell 2008 Apr;19(4):1680-92

PMID:29722930 - Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.

Zheng S et al. FEBS J 2018 Jul;285(13):2468-2480

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.

Wu JQ et al. Science 2005 Oct 14;310(5746):310-4

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:41171630 - Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis.

Singh D et al. Elife 2025 Oct 31;13

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:20123972 - Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast.

Onishi M et al. Mol Cell Biol 2010 Apr;30(8):2057-74

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053