protein coding gene - wsp1 (SPAC4F10.15c) - WASp homolog

Gene summary

Standard name

wsp1

Systematic ID

SPAC4F10.15c

Product

WASp homolog

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O36027

ORFeome ID

26/26G03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4861253..4863507 reverse strand

Annotation

Protein features

Orthologs

• WAS (HGNC:12731) Homo sapiens
• WASL (HGNC:12735) Homo sapiens
• wsp1 (SJAG_01732) Schizosaccharomyces japonicus
• LAS17 (YOR181W) Saccharomyces cerevisiae

References / Literature

PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904

PMID:24120641 - Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments.

Wagner AR et al. Curr Biol 2013 Oct 21;23(20):1990-8

PMID:25040903 - Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.

Encinar del Dedo J et al. Traffic 2014 Oct;15(10):1122-42

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)

PMID:35533728 - Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly.

Liu SL et al. J Biol Chem 2022 Jun;298(6):102019

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:18165685 - Pathway of actin filament branch formation by Arp2/3 complex.

Beltzner CC et al. J Biol Chem 2008 Mar 14;283(11):7135-44

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:12214236 - Actin dynamics in the contractile ring during cytokinesis in fission yeast.

Pelham RJ et al. Nature 2002 Sep 05;419(6902):82-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:33179595 - Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks.

Balzer CJ et al. Elife 2020 Nov 12;9

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29

PMID:21620704 - Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis.

Basu R et al. Curr Biol 2011 Jun 07;21(11):905-16

PMID:30471998 - Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex.

Balzer CJ et al. Curr Biol 2018 Dec 03;28(23):3886-3891.e4

PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:11076964 - Fission yeast myosin-I, Myo1p, stimulates actin assembly by Arp2/3 complex and shares functions with WASp.

Lee WL et al. J Cell Biol 2000 Nov 13;151(4):789-800

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12939254 - The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe.

Carnahan RH et al. J Cell Biol 2003 Sep 01;162(5):851-62

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:16864655 - Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast.

Wu JQ et al. J Cell Biol 2006 Jul 31;174(3):391-402

PMID:21885283 - Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast.

Arasada R et al. Curr Biol 2011 Sep 13;21(17):1450-9

PMID:21676862 - Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex.

Ti SC et al. Proc Natl Acad Sci U S A 2011 Aug 16;108(33):E463-71

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25543282 - Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.

Suarez C et al. Dev Cell 2015 Jan 12;32(1):43-53

PMID:15615784 - Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe.

Huang TY et al. J Cell Sci 2005 Jan 01;118(Pt 1):199-210

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:26960792 - Rga6 is a Fission Yeast Rho GAP Involved in Cdc42 Regulation of Polarized Growth.

Revilla-Guarinos MT et al. Mol Biol Cell 2016 Mar 09;27(9):1524-35

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:22891673 - Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton.

Jourdain I et al. Traffic 2012 Nov;13(11):1481-95

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:19805578 - Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.

Mata J FASEB J 2010 Feb;24(2):479-84

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23148219 - Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.

Liu SL et al. J Biol Chem 2013 Jan 04;288(1):487-97

PMID:37531259 - Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins.

Willet AH et al. Mol Biol Cell 2023 Oct 01;34(11):br17

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:16087707 - Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast.

Sirotkin V et al. J Cell Biol 2005 Aug 15;170(4):637-48

PMID:25451933 - Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.

Chen Q et al. J Biol Chem 2015 Jan 23;290(4):2289-300

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405