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protein coding gene - SPAC4F10.16c - plasma membrane phospholipid-translocating ATPase complex, ATPase subunit

Gene summary

Systematic ID
SPAC4F10.16c
Product
plasma membrane phospholipid-translocating ATPase complex, ATPase subunit
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O36028
ORFeome ID
30/30F11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4863739..4868318 reverse strand

Annotation

GO biological process

GO:0045332 - phospholipid translocation

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO:1990531 - phospholipid-translocating ATPase complex

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GO:0005886 - plasma membrane

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0140351 - glycosylceramide flippase activity

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GO:0000287 - magnesium ion binding

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GO:0140345 - phosphatidylcholine flippase activity

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GO:0090554 - phosphatidylcholine floppase activity

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GO:0090555 - phosphatidylethanolamine flippase activity

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GO:0090556 - phosphatidylserine floppase activity

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Modification

MOD:00047 - O-phospho-L-threonine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000026 - ribosomal density increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF13246Cation_ATPasePFAM
PF16212PhoLip_ATPase_CP_typ_ATPase_cPFAM
PF16209PhoLip_ATPase_NP-type_ATPase_NPFAM
cd02073P-type_ATPase_APLT_Dnf-likeCDD
PS00154ATPASE_E1_E2ATPase_P-typ_P_sitePROSITE_PATTERNS
PR00119CATATPASEPRINTS
G3DSA:3.40.1110.10:FF:000358FUNFAM
G3DSA:3.40.50.1000:FF:000001FUNFAM
SSF81653Calcium ATPase, transduction domain AATPase_P-typ_transduc_dom_A_sfSUPERFAMILY
SSF81660Metal cation-transporting ATPase, ATP-binding domain NATPase_P-typ_cyto_dom_NSUPERFAMILY
SSF56784HAD-likeHAD-like_sfSUPERFAMILY
SSF81665Calcium ATPase, transmembrane domain MATPase_P-typ_TM_dom_sfSUPERFAMILY
G3DSA:3.40.50.1000HAD_sfGENE3D
G3DSA:2.70.150.10GENE3D
G3DSA:3.40.1110.10ATPase_P-typ_cyto_dom_NGENE3D
PTHR24092PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASEPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte
TIGR01652ATPase-PlipidP-type_ATPase_IVNCBIFAM
TIGR01494ATPase_P-typeP_typ_ATPaseNCBIFAM
SFLDG00002C1.7:_P-type_atpase_likeSFLD
SFLDF00027p-type_atpaseP_typ_ATPase_HD_domSFLD
SFLDS00003Haloacid_DehalogenaseSFLD

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.
Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7