protein coding gene - sss1 (SPAC4G8.02c) - Sec61 translocon gamma subunit Sss1

Gene summary

Standard name: sss1
Systematic ID: SPAC4G8.02c
Product: Sec61 translocon gamma subunit Sss1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q09827
ORFeome ID: 04/04E12
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 756479..757109 reverse strand

Annotation

GO biological process

GO:0031204 - post-translational protein targeting to membrane, translocation

References:

GO_REF:0000033

GO:0045048 - protein insertion into ER membrane

References:

GO_REF:0000111

GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation

References:

GO_REF:0000024

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

PMID:16823372

GO:0005784 - Sec61 translocon complex

References:

GO_REF:0000024

GO:0071261 - Ssh1 translocon complex

References:

GO_REF:0000033

GO molecular function

GO:0008320 - transmembrane protein transporter activity

References:

GO_REF:0000033

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

sss1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

sss1delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00584	SecE	Translocase_SecE/Sec61-g	Pfam
PS01067	SECE_SEC61G	Translocase_SecE/Sec61-g	PROSITE patterns
G3DSA:1.20.5.820		Prot_translocase_SecE_dom_sf	CATH-Gene3D
SSF103456		Prot_translocase_SecE_dom_sf	SUPERFAMILY
PTHR12309			PANTHER
TIGR00327	secE_euk_arch	Translocase_Sec61-g	NCBIFAM
Transmembrane alpha helix			DeepTMHMM
MF_00422	SecE	Translocase_SecE/Sec61-g	HAMAP

Orthologs

SEC61G (HGNC:18277) Homo sapiens
sss1 (SJAG_00959) Schizosaccharomyces japonicus
SSS1 (YDR086C) Saccharomyces cerevisiae

References / Literature

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.: Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025