protein coding gene - rnh201 (SPAC4G9.02) - ribonuclease H2 complex subunit Rnh201

Gene summary

Standard name

rnh201

Systematic ID

SPAC4G9.02

Product

ribonuclease H2 complex subunit Rnh201

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10236

ORFeome ID

14/14B04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2254496..2255856 forward strand

Annotation

Protein features

Orthologs

• RNASEH2A (HGNC:18518) Homo sapiens
• rnh201 (SJAG_02039) Schizosaccharomyces japonicus
• RNH201 (YNL072W) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:41525994 - Transcriptional PBR cycles at pericentromeric repeats cause gross chromosomal rearrangements through Rad52-dependent ADR-loop formation.

Xu R et al. Nucleic Acids Res 2026 Jan 05;54(1)

GO_REF:0000002 - Comments

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:22144917 - The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved.

Miyabe I et al. PLoS Genet 2011 Dec;7(12):e1002407

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:34464389 - R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.

Ellis DA et al. PLoS Genet 2021 Aug;17(8):e1009784

PMID:25106870 - ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe.

Sastre-Moreno G et al. Nucleic Acids Res 2014 Sep;42(15):9821-37

PB_REF:0000003 - Disease Association Curation

PMID:29622660 - RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Zhao H et al. EMBO Rep 2018 May;19(5)

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:31294478 - Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription.

Rivosecchi J et al. EMBO J 2019 Aug 15;38(16):e101955

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:27881299 - Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair.

Ohle C et al. Cell 2016 Nov 03;167(4):1001-1013.e7

PMID:25664722 - A global profile of replicative polymerase usage.

Daigaku Y et al. Nat Struct Mol Biol 2015 Mar;22(3):192-198

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29844133 - Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations in Schizosaccharomyces pombe .

Marayati BF et al. Genetics 2018 Aug;209(4):967-981

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:33568651 - Replication dynamics of recombination-dependent replication forks.

Naiman K et al. Nat Commun 2021 Feb 10;12(1):923

PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.

Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23