PomBase home

protein coding gene - adk1 (SPAC4G9.03) - adenylate kinase Adk1

Gene summary

Standard name
adk1
Systematic ID
SPAC4G9.03
Product
adenylate kinase Adk1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P33075
ORFeome ID
42/42G09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2255868..2256730 forward strand

Annotation

Disease association

MONDO:0009973 - reticular dysgenesis

References:

GO biological process

GO:0006172 - ADP biosynthetic process

References:

GO:0046033 - AMP metabolic process

References:

GO:0046034 - ATP metabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005758 - mitochondrial intermembrane space

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004017 - AMP kinase activity

References:

GO:0005524 - ATP binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000340 - haploinsufficient

References:

Genotypes:

FYPO:0003641 - increased adenylate kinase activity

References:

Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

References:

Genotypes:

FYPO:0002379 - inviable after spore germination, without cell division, with elongated germ tube

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00406ADKPfam
PF05191ADK_lidAdenylate_kinase_lid-domPfam
cd01428ADKAdenylat/UMP-CMP_kinCDD
PS00113ADENYLATE_KINASEAdenylat_kinase_CSPROSITE patterns
PR00094ADENYLTKNASEAdenylat/UMP-CMP_kinPRINTS
G3DSA:3.40.50.300:FF:000106CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR23359Adenylat/UMP-CMP_kinPANTHER
NF001379adkNCBIFAM
NF001380PRK00279.1-2NCBIFAM
NF001381PRK00279.1-3NCBIFAM
NF011100PRK14527.1NCBIFAM
TIGR01351adkAdenyl_kin_subNCBIFAM
CoilCOILS
MF_00235Adenylate_kinase_AdkAdenylat/UMP-CMP_kinHAMAP
MF_03168Adenylate_kinase_AK2AK2HAMAP

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:8496185 - Molecular analysis of the essential gene for adenylate kinase from the fission yeast Schizosaccharomyces pombe.
Konrad M J Biol Chem 1993 May 25;268(15):11326-34
GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.
Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63