protein coding gene - pcf11 (SPAC4G9.04c) - mRNA cleavage and polyadenylation specificity factor complex RNA-binding subunit Pcf11

Gene summary

Standard name

pcf11

Systematic ID

SPAC4G9.04c

Product

mRNA cleavage and polyadenylation specificity factor complex RNA-binding subunit Pcf11

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10237

ORFeome ID

37/37B04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2255677..2259186 reverse strand

Annotation

Protein features

Orthologs

• PCF11 (HGNC:30097) Homo sapiens
• pcf11 (SJAG_02037) Schizosaccharomyces japonicus
• PCF11 (YDR228C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:26219431 - Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.

Mühlbacher W et al. Proteins 2015 Oct;83(10):1849-58

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:27582274 - Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein.

Larochelle M et al. Curr Genet 2017 May;63(2):195-199

PMID:31811152 - Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe.

Ding DQ et al. Nat Commun 2019 Dec 06;10(1):5598

PMID:39520300 - Proteins and noncoding RNAs that promote homologous chromosome recognition and pairing in fission yeast meiosis undergo condensate formation in vitro.

Ding DQ et al. FASEB J 2024 Nov 15;38(21):e70163

PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.

Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28367989 - The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S et al. Nat Commun 2017 Apr 03;8:14861

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39