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protein coding gene - arg3 (SPAC4G9.10) - ornithine carbamoyltransferase Arg3

Gene summary

Standard name
arg3
Systematic ID
SPAC4G9.10
Product
ornithine carbamoyltransferase Arg3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P31317
ORFeome ID
14/14C03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2273921..2275516 forward strand

Annotation

Disease association

MONDO:0005066 - metabolic disease

References:

MONDO:0010703 - ornithine carbamoyltransferase deficiency

References:

MONDO:0004739 - urea cycle disorder

References:

Experimental tools

PBO:0003176 - selectable marker, amino acid auxotroph

References:

GO biological process

GO:0006526 - L-arginine biosynthetic process

References:

GO:0019240 - L-citrulline biosynthetic process

References:

GO:0006591 - ornithine metabolic process

References:

GO:0000050 - urea cycle

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0016597 - amino acid binding

References:

GO:0004585 - ornithine carbamoyltransferase activity

References:

Genome organisation

PBO:0091283 - divergently oriented to functionally related gene

Multi-locus phenotype

FYPO:0003455 - decreased arginine catabolic process to proline

References:

Genotypes:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003434 - decreased ornithine carbamoyltransferase activity

References:

Genotypes:

FYPO:0000035 - growth auxotrophic for arginine

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0003435 - increased ornithine carbamoyltransferase activity

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00185OTCaceAsp_carbamoyltransf_Asp/Orn-bdPfam
PF02729OTCace_NAsp/Orn_carbamoyltranf_P-bdPfam
PS00097CARBAMOYLTRANSFERASEAsp/Orn_carbamoylTrfasePROSITE patterns
PR00100AOTCASEAsp/Orn_carbamoylTrfasePRINTS
PR00102OTCASEOrn/put_carbamltransPRINTS
G3DSA:3.40.50.1370:FF:000009CATH-FunFam
G3DSA:3.40.50.1370:FF:000017CATH-FunFam
G3DSA:3.40.50.1370Asp/Orn_carbamoylTrfase_sfCATH-Gene3D
SSF53671Asp/Orn_carbamoylTrfase_sfSUPERFAMILY
PTHR45753PANTHER
NF001986PRK00779.1NCBIFAM
TIGR00658orni_carb_trOrn/put_carbamltransNCBIFAM

Orthologs

References / Literature

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Mojardín L et al. Cell Cycle 2015;14(2):206-18
PMID:17248775 - Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.
Kohli J et al. Genetics 1977 Nov;87(3):471-89
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:1313366 - Cloning and sequencing of arg3 and arg11 genes of Schizosaccharomyces pombe on a 10-kb DNA fragment. Heterologous expression and mitochondrial targeting of their translation products.
Van Huffel C et al. Eur J Biochem 1992 Apr 01;205(1):33-43
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:17622533 - Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast.
Ma Y et al. Curr Genet 2007 Aug;52(2):97-105
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845
PMID:18849471 - Thiol-independent action of mitochondrial thioredoxin to support the urea cycle of arginine biosynthesis in Schizosaccharomyces pombe.
Song JY et al. Eukaryot Cell 2008 Dec;7(12):2160-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PB_REF:0000003 - Disease Association Curation
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:29856841 - Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast.
Yang Y et al. PLoS One 2018;13(6):e0198516
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:7784193 - arg3+, a new selection marker system for Schizosaccharomyces pombe: application of ura4+ as a removable integration marker.
Waddell S et al. Nucleic Acids Res 1995 May 25;23(10):1836-7