protein coding gene - ifa38 (SPAC4G9.15) - ketoreductase involved in fatty acid elongation

Gene summary

Standard name: ifa38
Systematic ID: SPAC4G9.15
Product: ketoreductase involved in fatty acid elongation
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q10245
ORFeome ID: 17/17H02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 2282203..2283537 forward strand

Annotation

Disease association

MONDO:0009916 - 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency

References:

PB_REF:0000006

GO biological process

GO:0030497 - fatty acid elongation

References:

GO_REF:0000033

GO:0030148 - sphingolipid biosynthetic process

References:

GO_REF:0000024

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

PMID:16823372

GO:0005789 - endoplasmic reticulum membrane

References:

GO_REF:0000104

GO molecular function

GO:0045703 - ketoreductase activity

References:

GO_REF:0000024

GO:0141040 - very-long-chain 3-oxoacyl-CoA reductase activity

References:

GO_REF:0000116

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001309 - increased viability in stationary phase

References:

PMID:35820914

Genotypes:

ifa38delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

ifa38delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

ifa38delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF00106	adh_short	SDR_fam	PFAM
cd05356	17beta-HSD1_like_SDR_c		CDD
PS00061	ADH_SHORT	Sc_DH/Rdtase_CS	PROSITE_PATTERNS
PR00081	GDHRDH	SDR_fam	PRINTS
SSF51735	NAD(P)-binding Rossmann-fold domains	NAD(P)-bd_dom_sf	SUPERFAMILY
G3DSA:3.40.50.720			GENE3D
PTHR43086	VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE		PANTHER
PIRSF000126	11-beta-HSD1		PIRSF
Coil	Coil		COILS
MF_03107	3_ketoreductase	3_ketoreductase_fungal	HAMAP

Orthologs

HSDL1 (HGNC:16475) Homo sapiens
HSD17B12 (HGNC:18646) Homo sapiens
HSD17B3 (HGNC:5212) Homo sapiens
ifa38 (SJAG_00630) Schizosaccharomyces japonicus
IFA38 (YBR159W) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.: Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .: Wiley DJ et al. Front Physiol 2020;11:427
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.: Vega M et al. BMC Biol 2022 Jul 12;20(1):160