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protein coding gene - ams1 (SPAC513.05) - Class II alpha-mannosidase, subtype C, Ams1

Gene summary

Standard name
ams1
Systematic ID
SPAC513.05
Product
Class II alpha-mannosidase, subtype C, Ams1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mns2
UniProt ID
Q9UT61
ORFeome ID
30/30B12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2914479..2920278 forward strand

Annotation

Disease association

MONDO:0030770 - congenital disorder of deglycosylation 2

References:

GO biological process

GO:0006013 - mannose metabolic process

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GO:0009313 - oligosaccharide catabolic process

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GO cellular component

GO:0005829 - cytosol

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GO:0000328 - fungal-type vacuole lumen

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GO:0000329 - fungal-type vacuole membrane

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GO molecular function

GO:0030246 - carbohydrate binding

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GO:0052768 - mannosyl-oligosaccharide 1,3-alpha-mannosidase activity

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GO:0052767 - mannosyl-oligosaccharide 1,6-alpha-mannosidase activity

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GO:0005515 - protein binding

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GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0001142 - normal Man8GlcNAc level

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Genotypes:

FYPO:0001143 - normal Man9GlcNAc level

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009066 - resistance to amorolfine

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Subunit composition

PBO:0015242 - homomeric(4)

References:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01074Glyco_hydro_38NGlyco_hydro_38_NPfam
PF07748Glyco_hydro_38CGlyco_hydro_38_CPfam
PF09261Alpha-mann_midGlyco_hydro_38_cenPfam
PF17677Glyco_hydro38C2GH38_CPfam
PF22907Ams1-like_1stAms1-like_NPfam
cd10812GH38N_AMII_ScAms1_likeCDD
SM00872Alpha-mann_midGlyco_hydro_38_cenSMART
G3DSA:1.20.1270.50:FF:000004CATH-FunFam
G3DSA:2.70.98.30:FF:000001CATH-FunFam
G3DSA:3.20.110.10:FF:000002CATH-FunFam
G3DSA:1.20.1270.50Glyco_hydro_38_cen_sfCATH-Gene3D
G3DSA:2.60.40.2220CATH-Gene3D
G3DSA:2.70.98.30CATH-Gene3D
G3DSA:3.20.110.10Glyco_hydro_38_N_sfCATH-Gene3D
SSF74650Gal_mutarotase_sf_domSUPERFAMILY
SSF88688Glyco_hydro_57/38_cen_sfSUPERFAMILY
SSF88713Glyco_hydro/deAcase_b/a-brlSUPERFAMILY
PTHR46017PANTHER

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34169534 - Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.
Wang YY et al. EMBO J 2021 Aug 02;40(15):e107497
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
GO_REF:0000002 - Comments
PMID:16079177 - Characterization of Schizosaccharomyces pombe ER alpha-mannosidase: a reevaluation of the role of the enzyme on ER-associated degradation.
Movsichoff F et al. Mol Biol Cell 2005 Oct;16(10):4714-24
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.
Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93
PMID:36095070 - The hallmark domain of the oldest autophagy receptor family is a cargo-binding module.
Pan ZQ et al. Autophagy 2023 Apr;19(4):1359-1360
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:32981237 - Cryo-EM structure of fission yeast tetrameric α-mannosidase Ams1.
Zhang J et al. FEBS Open Bio 2020 Nov;10(11):2437-2451
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623