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protein coding gene - alg13 (SPAC56E4.02c) - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Alg13

Gene summary

Standard name
alg13
Systematic ID
SPAC56E4.02c
Product
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Alg13
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14190
ORFeome ID
04/04F02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1242020..1243039 reverse strand

Annotation

Disease association

MONDO:0010472 - developmental and epileptic encephalopathy, 36

References:

MONDO:0005027 - epilepsy

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0006488 - dolichol-linked oligosaccharide biosynthetic process

References:

GO cellular component

GO:0098554 - cytoplasmic side of endoplasmic reticulum membrane

References:

GO:0043541 - UDP-N-acetylglucosamine transferase complex

References:

GO molecular function

GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04101Glyco_tran_28_CGlyco_trans_28_CPfam
G3DSA:3.40.50.2000:FF:000244CATH-FunFam
G3DSA:3.40.50.2000CATH-Gene3D
SSF53756SUPERFAMILY
PTHR12867Alg13-likePANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:9878760 - The dolichol pathway of N-linked glycosylation.
Burda P et al. Biochim Biophys Acta 1999 Jan 06;1426(2):239-57
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23934111 - De novo mutations in epileptic encephalopathies.
Epi4K Consortium et al. Nature 2013 Sep 12;501(7466):217-21
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870