protein coding gene - ppt1 (SPAC56F8.04c) - para-hydroxybenzoate--polyprenyltransferase Ppt1

Gene summary

Standard name

ppt1

Systematic ID

SPAC56F8.04c

Product

para-hydroxybenzoate--polyprenyltransferase Ppt1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

coq2

UniProt ID

Q10252

ORFeome ID

16/16F05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1133226..1134334 reverse strand

Annotation

Protein features

Orthologs

• COQ2 (HGNC:25223) Homo sapiens
• ppt1 (SJAG_06603) Schizosaccharomyces japonicus
• COQ2 (YNR041C) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:17069919 - Phenotypes and fed-batch fermentation of ubiquinone-overproducing fission yeast using ppt1 gene.

Zhang D et al. J Biotechnol 2007 Jan 30;128(1):120-31

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Tay Z et al. PLoS One 2013;8(1):e55041

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:24911838 - Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.

Hayashi K et al. PLoS One 2014;9(6):e99038

PMID:33232355 - Benzoic acid inhibits Coenzyme Q biosynthesis in Schizosaccharomyces pombe.

Nishida I et al. PLoS One 2020;15(11):e0242616

PMID:25669599 - Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Nguyen TT et al. Sci Rep 2015 Feb 11;5:8400

PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.

Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)

PMID:16400613 - A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency.

Quinzii C et al. Am J Hum Genet 2006 Feb;78(2):345-9

PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.

Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658

PMID:14695938 - Pleiotropic phenotypes of fission yeast defective in ubiquinone-10 production. A study from the abc1Sp (coq8Sp) mutant.

Saiki R et al. Biofactors 2003;18(1-4):229-35

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:37859837 - In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions.

Mori A et al. R Soc Open Sci 2023 Oct;10(10):230404

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PB_REF:0000003 - Disease Association Curation

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.

Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:42024429 - Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5.

Nishihara S et al. Biosci Biotechnol Biochem 2026 Apr 23;

PMID:11092853 - Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase.

Uchida N et al. J Bacteriol 2000 Dec;182(24):6933-9

GO_REF:0000104 - Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.

Nishida I et al. J Biol Chem 2023 Jun;299(6):104797