protein coding gene - cdr2 (SPAC57A10.02) - serine/threonine protein kinase Cdr2

Gene summary

Standard name

cdr2

Systematic ID

SPAC57A10.02

Product

serine/threonine protein kinase Cdr2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P87050

ORFeome ID

28/28D01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1364796..1367968 forward strand

Annotation

Protein features

Orthologs

• cdr2 (SJAG_03602) Schizosaccharomyces japonicus
• KCC4 (YCL024W) Saccharomyces cerevisiae
• GIN4 (YDR507C) Saccharomyces cerevisiae
• HSL1 (YKL101W) Saccharomyces cerevisiae

References / Literature

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PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

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PMID:21422229 - Assembly and architecture of precursor nodes during fission yeast cytokinesis.

Laporte D et al. J Cell Biol 2011 Mar 21;192(6):1005-21

PMID:22665807 - Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches.

Lu LX et al. Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9899-904

PMID:22768388 - Translational control of cell division by Elongator.

Bauer F et al. Cell Rep 2012 May 31;1(5):424-33

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:35082773 - Phosphoinositide-Dependent Protein Kinases Regulate Cell Cycle Progression Through the SAD Kinase Cdr2 in Fission Yeast.

Liu K et al. Front Microbiol 2021;12:807148

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:33419777 - Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast.

Scotchman E et al. J Cell Sci 2021 Feb 11;134(3)

PMID:31050341 - Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry.

Allard CAH et al. Elife 2019 May 03;8

PMID:23149940 - Blt1 and Mid1 provide overlapping membrane anchors to position the division plane in fission yeast.

Guzman-Vendrell M et al. Mol Cell Biol 2013 Jan;33(2):418-28

PMID:9843577 - The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe.

Breeding CS et al. Mol Biol Cell 1998 Dec;9(12):3399-415

PMID:22684255 - The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

Grallert A et al. Nat Cell Biol 2012 Jun 10;14(7):738-45

PMID:28515144 - Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress.

Schutt KL et al. Mol Biol Cell 2017 Jul 01;28(13):1804-1814

PMID:3448096 - Schizosaccharomyces pombe mutants affected in their division response to starvation.

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PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:1588914 - Five novel elements involved in the regulation of mitosis in fission yeast.

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PMID:22298427 - Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.

Ye Y et al. Mol Biol Cell 2012 Apr;23(7):1181-95

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:21703453 - A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.

Hachet O et al. Cell 2011 Jun 24;145(7):1116-28

PMID:9843572 - The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.

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PMID:22918943 - Anillin-related protein Mid1p coordinates the assembly of the cytokinetic contractile ring in fission yeast.

Saha S et al. Mol Biol Cell 2012 Oct;23(20):3982-92

PMID:24047646 - Pom1 and cell size homeostasis in fission yeast.

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PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.

Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60

PMID:25501814 - The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.

Pu KM et al. J Cell Sci 2015 Feb 01;128(3):441-6

PMID:26071525 - Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.

Guzmán-Vendrell M et al. J Cell Sci 2015 Aug 01;128(15):2842-53

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:24508166 - Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Deng L et al. Curr Biol 2014 Feb 17;24(4):428-33

PMID:24424027 - Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells.

Atkin J et al. J Cell Sci 2014 Mar 15;127(Pt 6):1346-56

PMID:31553675 - The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.

Schutt KL et al. Mol Biol Cell 2019 Nov 01;30(23):2880-2889

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19427212 - Spatial control of cytokinesis by Cdr2 kinase and Mid1/anillin nuclear export.

Almonacid M et al. Curr Biol 2009 Jun 09;19(11):961-6

PMID:15454577 - The GIN4 family kinase, Cdr2p, acts independently of septins in fission yeast.

Morrell JL et al. J Cell Sci 2004 Oct 15;117(Pt 22):5293-302

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.

Chua G et al. Genetics 2002 Oct;162(2):689-703

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.

Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2

PMID:24982431 - Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.

Rincon SA et al. J Cell Biol 2014 Jul 07;206(1):61-77

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28924043 - Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.

Opalko HE et al. J Biol Chem 2017 Nov 10;292(45):18457-18468

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:2245912 - stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.

Hudson JD et al. Genetics 1990 Oct;126(2):309-15

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:12589755 - The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Kanoh J et al. J Mol Biol 2003 Feb 28;326(4):1081-94

PMID:28162898 - SIN-Dependent Dissociation of the SAD Kinase Cdr2 from the Cell Cortex Resets the Division Plane.

Rincon SA et al. Curr Biol 2017 Feb 20;27(4):534-542

PMID:31644361 - A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

Opalko HE et al. Mol Biol Cell 2019 Dec 01;30(25):3015-3023

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:28539404 - Analysis of interphase node proteins in fission yeast by quantitative and superresolution fluorescence microscopy.

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PMID:18257517 - Phosphoproteome analysis of fission yeast.

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PMID:29514920 - Cell size-dependent regulation of Wee1 localization by Cdr2 cortical nodes.

Allard CAH et al. J Cell Biol 2018 May 07;217(5):1589-1599

PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.

Jourdain I et al. PLoS One 2013;8(1):e54142

PMID:30639107 - Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.

Facchetti G et al. Curr Biol 2019 Jan 21;29(2):350-358.e4

PMID:9001228 - A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.

Matsumoto T Mol Cell Biol 1997 Feb;17(2):742-50

PMID:20194963 - Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

Calonge TM et al. Genetics 2010 May;185(1):81-93

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:10835386 - Slm9, a novel nuclear protein involved in mitotic control in fission yeast.

Kanoh J et al. Genetics 2000 Jun;155(2):623-31

PMID:22427686 - Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis.

Lee IJ et al. J Cell Sci 2012 Jun 15;125(Pt 12):2973-85

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:1549179 - The wee1 protein kinase is required for radiation-induced mitotic delay.

Rowley R et al. Nature 1992 Mar 26;356(6367):353-5

PMID:34958661 - Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.

Opalko HE et al. J Cell Biol 2022 Feb 07;221(2)

PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.

Martin SG et al. Nature 2009 Jun 11;459(7248):852-6

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:22291963 - Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Tanae K et al. PLoS One 2012;7(1):e30472

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:36574843 - Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.

Berg RA et al. J Biol Chem 2023 Feb;299(2):102831

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:26575035 - Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe.

Gómez-Hierro A et al. PLoS One 2015;10(11):e0143037

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:28223368 - Phosphatases Generate Signal Specificity Downstream of Ssp1 Kinase in Fission Yeast.

Deng L et al. Mol Cell Biol 2017 May 15;37(10)

PMID:19546237 - TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.

Schonbrun M et al. Mol Cell Biol 2009 Aug;29(16):4584-94

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:24316795 - Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.

Bhatia P et al. Cell Cycle 2014;13(4):538-52

PMID:37463585 - The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time.

Miller KE et al. Curr Biol 2023 Aug 21;33(16):3312-3324.e7

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8