protein coding gene - pof1 (SPAC57A10.05c) - F-box/WD repeat protein, probable hydrogen sulfide sensing ubiquitin ligase adaptor Pof1

Gene summary

Standard name

pof1

Systematic ID

SPAC57A10.05c

Product

F-box/WD repeat protein, probable hydrogen sulfide sensing ubiquitin ligase adaptor Pof1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P87053

ORFeome ID

36/36F07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1372722..1375595 reverse strand

Annotation

Protein features

Orthologs

• FBXO24 (HGNC:13595) Homo sapiens
• FBXW2 (HGNC:13608) Homo sapiens
• FBXW7 (HGNC:16712) Homo sapiens
• pof1 (SJAG_00192) Schizosaccharomyces japonicus
• MET30 (YIL046W) Saccharomyces cerevisiae

References / Literature

PMID:29361524 - F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast.

Qiu C et al. J Cell Sci 2018 Feb 02;131(3)

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:11820777 - Isolation and characterization of a novel F-box protein Pof10 in fission yeast.

Ikebe C et al. Biochem Biophys Res Commun 2002 Feb 08;290(5):1399-407

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:39580958 - Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.

Tang J et al. Biochem Biophys Res Commun 2024 Nov 20;741:151014

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Wu S et al. Nat Commun 2013;4:1642

PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Lehmann A et al. Genes Cells 2004 May;9(5):367-82

PMID:19748355 - F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

Schmidt MW et al. Mol Cell 2009 Sep 11;35(5):586-97

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:15660136 - SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast.

Harrison C et al. EMBO J 2005 Feb 09;24(3):599-610

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36