protein coding gene - mtx2 (SPAC589.04) - SAM complex subunit, metaxin 2, Sam35

Gene summary

Standard name: mtx2
Systematic ID: SPAC589.04
Product: SAM complex subunit, metaxin 2, Sam35
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: sam35
UniProt ID: Q9HE00
ORFeome ID: 41/41G04
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3100075..3101322 forward strand

Annotation

Disease association

MONDO:0030880 - mandibuloacral dysplasia progeroid syndrome

References:

PB_REF:0000006

GO biological process

GO:0045040 - protein insertion into mitochondrial outer membrane

References:

GO_REF:0000033

GO cellular component

GO:0001401 - SAM complex

References:

GO_REF:0000033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

mtx2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

mtx2delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30647105

Genotypes:

mtx2delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091450 - was previously incorrectly named as mtx1 with MTX1 human ortholog

Protein features

ID	Name	InterPro name	DB name
PF17171	GST_C_6	Metaxin_GST	PFAM
PF17172	GST_N_4	Thioredoxin-like_fold	PFAM
cd03193	GST_C_Metaxin		CDD
SSF47616	GST C-terminal domain-like	Glutathione-S-Trfase_C_sf	SUPERFAMILY
PTHR12289	METAXIN RELATED	Mito_Protein_Transport_Metaxin	PANTHER

Orthologs

MTX2 (HGNC:7506) Homo sapiens
mtx2 (SJAG_01780) Schizosaccharomyces japonicus
SAM35 (YHR083W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.: Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36