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protein coding gene - mtx2 (SPAC589.04) - SAM complex subunit, metaxin 2, Sam35

Gene summary

Standard name
mtx2
Systematic ID
SPAC589.04
Product
SAM complex subunit, metaxin 2, Sam35
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sam35
UniProt ID
Q9HE00
ORFeome ID
41/41G04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3100075..3101322 forward strand

Annotation

Disease association

MONDO:0030880 - mandibuloacral dysplasia progeroid syndrome

References:

GO biological process

GO:7770063 - beta barrel protein insertion into mitochondrial outer membrane

References:

GO cellular component

GO:0001401 - SAM complex

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091450 - was previously incorrectly named as mtx1 with MTX1 human ortholog

Protein features

IDNameInterPro nameDB name
PF17171GST_C_6Metaxin_GSTPfam
PF17172GST_N_4Thioredoxin-like_foldPfam
cd03193GST_C_MetaxinCDD
SSF47616Glutathione-S-Trfase_C_sfSUPERFAMILY
PTHR12289Mito_Protein_Transport_MetaxinPANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs