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protein coding gene - qng1 (SPAC589.05c) - tRNA queuosine nucleoside glycosylase Qng1

Gene summary

Standard name
qng1
Systematic ID
SPAC589.05c
Product
tRNA queuosine nucleoside glycosylase Qng1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
qtr3
UniProt ID
Q9HDZ9
ORFeome ID
50/50D11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3101103..3102548 reverse strand

Annotation

Complementation

PBO:0091452 - functionally complemented by human QNG1

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GO biological process

GO:0043174 - nucleoside salvage

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GO:0002099 - tRNA wobble guanine modification

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GO cellular component

GO:0005829 - cytosol

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GO molecular function

GO:0106432 - queuosine nucleosidase activity

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003427 - decreased queuosine level in tRNA

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Genotypes:

FYPO:0003480 - queuosine absent from tRNA

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10343Q_salvageQ_salvagePfam
PTHR21314Q_salvagePANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24911101 - Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family.
Zallot R et al. ACS Chem Biol 2014 Aug 15;9(8):1812-25
PMID:35940128 - Queuosine salvage in fission yeast by Qng1-mediated hydrolysis to queuine.
Patel BI et al. Biochem Biophys Res Commun 2022 Oct 08;624:146-150
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480