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protein coding gene - mes1 (SPAC5D6.08c) - meiotic APC inhibitor Mes1

Gene summary

Standard name
mes1
Systematic ID
SPAC5D6.08c
Product
meiotic APC inhibitor Mes1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P41005
ORFeome ID
02/02G08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1498898..1500084 forward strand

Annotation

Comment

PBO:0091288 - meiosis specific splicing

References:

GO biological process

GO:1990946 - meiosis I/meiosis II transition

References:

GO:1990949 - metaphase/anaphase transition of meiosis I

References:

GO:1902103 - negative regulation of metaphase/anaphase transition of meiotic cell cycle

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0005515 - protein binding

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GO:1990948 - ubiquitin ligase inhibitor activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002092 - abnormal meiotic sister chromatid cohesion

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Genotypes:

FYPO:0003379 - abolished meiosis II

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Genotypes:

FYPO:0005382 - delayed exit from meiosis

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Genotypes:

FYPO:0005412 - delayed onset of meiosis II

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002223 - abnormal cell cycle arrest in meiosis II

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Genotypes:

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

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Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0002092 - abnormal meiotic sister chromatid cohesion

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Genotypes:

FYPO:0001914 - abnormal prospore membrane formation

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Genotypes:

FYPO:0002275 - abnormal protein degradation

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Genotypes:

FYPO:0006977 - abnormal protein ubiquitination

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Genotypes:

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

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Genotypes:

FYPO:0002817 - abnormally arrested meiosis I

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Genotypes:

FYPO:0003593 - abolished anaphase-promoting complex-dependent protein catabolic process

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Genotypes:

FYPO:0003379 - abolished meiosis II

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0004799 - abolished zygotic meiosis II

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Genotypes:

FYPO:0003585 - decreased anaphase-promoting complex-dependent protein catabolic process

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Genotypes:

FYPO:0003380 - decreased frequency of meiosis I

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Genotypes:

FYPO:0004633 - decreased protein kinase activity during meiosis II

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Genotypes:

FYPO:0003550 - decreased protein level during meiosis

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Genotypes:

FYPO:0004938 - decreased protein level during meiosis I

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Genotypes:

FYPO:0004632 - decreased protein level during meiosis II

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Genotypes:

FYPO:0004631 - decreased protein level during meiotic anaphase I

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Genotypes:

FYPO:0004102 - decreased protein polyubiquitination during vegetative growth

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0004994 - delayed onset of meiosis I

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Genotypes:

FYPO:0003611 - increased protein level during meiosis

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Genotypes:

FYPO:0005414 - increased protein level during meiosis II

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Genotypes:

FYPO:0004157 - increased protein level during mitosis

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Genotypes:

FYPO:0004635 - increased protein localization to mitotic spindle

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Genotypes:

FYPO:0001571 - increased protein-protein interaction

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0005384 - meiosis I metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0004634 - normal protein level during meiosis

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Genotypes:

FYPO:0003538 - premature meiosis I

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Protein features

IDNameInterPro nameDB name
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:15791259 - Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
Izawa D et al. Nature 2005 Mar 24;434(7032):529-33
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:3861929 - Characterization of meiosis-deficient mutants by electron microscopy and mapping of four essential genes in the fission yeast Schizosaccharomyces pombe.
Shimoda C et al. Mol Gen Genet 1985;200(2):252-7
PMID:8082199 - Meiosis-dependent mRNA splicing of the fission yeast Schizosaccharomyces pombe mes1+ gene.
Kishida M et al. Curr Genet 1994 Jun;25(6):497-503
PMID:24506453 - The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.
Arata M et al. Genes Cells 2014 Mar;19(3):225-38
PMID:18331722 - A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.
Kimata Y et al. Dev Cell 2008 Mar;14(3):446-54
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28245054 - Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.
Chikashige Y et al. FEBS Lett 2017 Apr;591(7):1029-1040
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:9528784 - The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain.
Horie S et al. Mol Cell Biol 1998 Apr;18(4):2118-29
PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.
Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94
PMID:23628763 - Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.
Aoi Y et al. EMBO Rep 2013 Jun;14(6):553-60
PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.
Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469
PMID:11459187 - The 5' terminal region of the Schizosaccharomyces pombe mes1 mRNA is crucial for its meiosis-specific splicing.
Shimoseki M et al. Mol Genet Genomics 2001 Jun;265(4):673-82
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:31532702 - Kinetochore-mediated outward force promotes spindle pole separation in fission yeast.
Shirasugi Y et al. Mol Biol Cell 2019 Oct 15;30(22):2802-2813
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7