PomBase home

protein coding gene - spo3 (SPAC607.10) - sporulation protein Spo3

Gene summary

Standard name
spo3
Systematic ID
SPAC607.10
Product
sporulation protein Spo3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9US08
ORFeome ID
29/29H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2052798..2057177 forward strand

Annotation

GO biological process

GO:0032120 - ascospore-type prospore membrane formation

References:

GO cellular component

GO:0005628 - prospore membrane

References:

GO:0070056 - prospore membrane leading edge

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Multi-locus phenotype

FYPO:0002708 - abolished prospore formation

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0006777 - prospore membrane formation excluding nucleus

References:

Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

Qualitative gene expression

PomGeneEx:0000022 - protein absent

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000015 - RNA absent

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0001914 - abnormal prospore membrane formation

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0000583 - abolished sporulation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0003563 - normal meiosis I

References:

Genotypes:

FYPO:0003798 - normal meiosis II

References:

Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

References:

Genotypes:

FYPO:0003845 - normal protein localization to prospore membrane

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000346 - small spores

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Orthologs

References / Literature

PMID:12557273 - Role of phosphatidylinositol 3-phosphate in formation of forespore membrane in Schizosaccharomyces pombe.
Onishi M et al. Yeast 2003 Feb;20(3):193-206
PMID:18550796 - Live observation of forespore membrane formation in fission yeast.
Nakamura T et al. Mol Biol Cell 2008 Aug;19(8):3544-53
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.
Hirata A et al. Arch Microbiol 1992;158(4):249-55
PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.
Kishida M et al. Curr Genet 1986;10(6):443-7
PMID:11739793 - The Schizosaccharomyces pombe spo3+ gene is required for assembly of the forespore membrane and genetically interacts with psy1(+)-encoding syntaxin-like protein.
Nakamura T et al. Mol Biol Cell 2001 Dec;12(12):3955-72
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18562696 - The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast.
Yan H et al. Mol Biol Cell 2008 Sep;19(9):3676-90
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:15189449 - Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.
Koga T et al. Genes Cells 2004 Jun;9(6):561-74
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:25146394 - The meiosis-specific nuclear passenger protein is required for proper assembly of forespore membrane in fission yeast.
Takaine M et al. J Cell Sci 2014 Oct 15;127(Pt 20):4429-42
PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.
Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93
PMID:18397994 - Slk1 is a meiosis-specific Sid2-related kinase that coordinates meiotic nuclear division with growth of the forespore membrane.
Pérez-Hidalgo L et al. J Cell Sci 2008 May 01;121(Pt 9):1383-92
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:20123972 - Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast.
Onishi M et al. Mol Cell Biol 2010 Apr;30(8):2057-74
PMID:12759375 - Fission yeast meu14+ is required for proper nuclear division and accurate forespore membrane formation during meiosis II.
Okuzaki D et al. J Cell Sci 2003 Jul 01;116(Pt 13):2721-35
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.
Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82
PMID:20980623 - A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast.
Li WZ et al. Mol Biol Cell 2010 Dec;21(24):4349-60