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protein coding gene - acp2 (SPAC631.01c) - F-actin capping protein beta subunit Acp2

Gene summary

Standard name
acp2
Systematic ID
SPAC631.01c
Product
F-actin capping protein beta subunit Acp2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9HGP5
ORFeome ID
32/32D06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2104030..2105433 reverse strand

Annotation

GO biological process

GO:0000147 - actin cortical patch assembly

References:

GO:0051016 - barbed-end actin filament capping

References:

GO:0000902 - cell morphogenesis

References:

GO:1904600 - mating projection actin fusion focus assembly

References:

GO:1903475 - mitotic actomyosin contractile ring assembly

References:

GO:1902404 - mitotic actomyosin contractile ring contraction

References:

GO cellular component

GO:0099079 - actin body

References:

GO:0030479 - actin cortical patch

References:

GO:0032153 - cell division site

References:

GO:0005829 - cytosol

References:

GO:0008290 - F-actin capping protein complex

References:

GO:1990819 - mating projection actin fusion focus

References:

GO:0043332 - mating projection tip

References:

GO:0031097 - medial cortex

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0051015 - actin filament binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000350 - abnormal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0000161 - abnormal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0003338 - abnormal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000742 - abnormal protein localization to actin cortical patch

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0000413 - abolished cell fusion during mating

References:

Genotypes:

FYPO:0003315 - actin cables absent from cell

References:

Genotypes:

FYPO:0004972 - actin cortical patches present in increased numbers

References:

Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0002050 - branched elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0001512 - branched, elongated cell

References:

Genotypes:

FYPO:0007096 - decreased protein localization to actin fusion focus

References:

Genotypes:

FYPO:0006207 - decreased rate of actin filament depolymerization

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0007097 - ectopic actin fusion focus assembly

References:

Genotypes:

FYPO:0006023 - elongated multinucleate multiseptate vegetative cell, irregular septum position

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0001011 - filamentous actin absent

References:

Genotypes:

FYPO:0005870 - incomplete septum

References:

Genotypes:

FYPO:0007094 - increased duration of cell fusion during mating

References:

Genotypes:

FYPO:0007095 - increased protein localization to actin fusion focus

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0001493 - inviable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0002025 - inviable elongated multinucleate vegetative cell with abnormal septum morphology

References:

Genotypes:

FYPO:0002107 - inviable stubby vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003988 - mislocalized actin cortical patches during vegetative growth

References:

Genotypes:

FYPO:0002487 - normal actin cable morphology

References:

Genotypes:

FYPO:0001294 - normal actin cortical patch localization

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0002253 - normal septum location

References:

Genotypes:

FYPO:0006213 - normal septum morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0002438 - short, misoriented actin cables

References:

Genotypes:

FYPO:0002439 - short, thick, misoriented actin cables

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002030 - abnormal actin cable organization

References:

Genotypes:

FYPO:0006108 - abnormal actin fusion focus assembly

References:

Genotypes:

FYPO:0003338 - abnormal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000742 - abnormal protein localization to actin cortical patch

References:

Genotypes:

FYPO:0001584 - abnormal protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0006116 - abolished protein localization to actin cortical patch

References:

Genotypes:

FYPO:0006215 - actin cables present in decreased numbers

References:

Genotypes:

FYPO:0001512 - branched, elongated cell

References:

Genotypes:

FYPO:0006120 - decreased protein localization to actin cortical patch

References:

Genotypes:

FYPO:0007096 - decreased protein localization to actin fusion focus

References:

Genotypes:

FYPO:0006207 - decreased rate of actin filament depolymerization

References:

Genotypes:

FYPO:0001365 - decreased rate of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0004653 - delayed onset of actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0007097 - ectopic actin fusion focus assembly

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0008400 - exocytic vesicles present in decreased numbers at the fusion focus of mating cells

References:

Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0009074 - increased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0007094 - increased duration of cell fusion during mating

References:

Genotypes:

FYPO:0006081 - increased protein localization to actin cortical patch

References:

Genotypes:

FYPO:0007095 - increased protein localization to actin fusion focus

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0004295 - multiseptate cell

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0001368 - normal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0004097 - normal actomyosin contractile ring contraction

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000744 - normal protein localization to actin cortical patch

References:

Genotypes:

FYPO:0001587 - normal protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0002253 - normal septum location

References:

Genotypes:

FYPO:0006213 - normal septum morphology

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0006014 - promiscuous mating

References:

Genotypes:

FYPO:0002445 - protein mislocalized to actin cortical patch

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0009070 - resistance to itraconazole

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005969 - resistance to magnesium chloride

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01115F_actin_cap_BCAPZBPFAM
PS00231F_ACTIN_CAPPING_BETAF-actin_capping_bsu_CSPROSITE_PATTERNS
PR00192FACTINCAPBCAPZBPRINTS
G3DSA:1.20.58.570:FF:000001FUNFAM
SSF90096Subunits of heterodimeric actin filament capping protein CapzCapZ_alpha/betaSUPERFAMILY
G3DSA:3.90.1150.210CapZ_alpha/beta_2GENE3D
G3DSA:1.20.58.570CAPZB_NGENE3D
PTHR10619F-ACTIN-CAPPING PROTEIN SUBUNIT BETACAPZBPANTHER

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:31495586 - Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.
Billault-Chaumartin I et al. Curr Biol 2019 Oct 07;29(19):3165-3176.e6
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25143407 - Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast.
Berro J et al. Mol Biol Cell 2014 Nov 05;25(22):3515-27
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.
Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:16256112 - Stg 1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast.
Nakano K et al. FEBS Lett 2005 Nov 21;579(28):6311-6
PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:27206859 - TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.
Baker K et al. J Cell Sci 2016 Jul 01;129(13):2613-24
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.
Wu JQ et al. Science 2005 Oct 14;310(5746):310-4
PMID:25451933 - Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.
Chen Q et al. J Biol Chem 2015 Jan 23;290(4):2289-300
PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .
Budden AM et al. Elife 2023 Aug 24;12
PMID:21642440 - Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
Skau CT et al. J Biol Chem 2011 Jul 29;286(30):26964-77
PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Wu JQ et al. Dev Cell 2003 Nov;5(5):723-34
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.
Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904
PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.
Nakano K et al. Genes Cells 2006 Aug;11(8):893-905
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:29856841 - Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast.
Yang Y et al. PLoS One 2018;13(6):e0198516
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:36202103 - Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion.
Billault-Chaumartin I et al. Curr Biol 2022 Nov 07;32(21):4752-4761.e10
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.
Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36