protein coding gene - rpn10 (SPAC637.10c) - 19S proteasome regulatory subunit Rpn10

Gene summary

Standard name

rpn10

Systematic ID

SPAC637.10c

Product

19S proteasome regulatory subunit Rpn10

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pus1

UniProt ID

O94444

ORFeome ID

12/12G01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4557551..4558696 reverse strand

Annotation

Protein features

Orthologs

• PSMD4 (HGNC:9561) Homo sapiens
• rpn10 (SJAG_02992) Schizosaccharomyces japonicus
• RPN10 (YHR200W) Saccharomyces cerevisiae

References / Literature

PMID:17761670 - Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.

Sha Z et al. J Biol Chem 2007 Nov 02;282(44):32414-23

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:22307589 - Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Lasker K et al. Proc Natl Acad Sci U S A 2012 Jan 31;109(5):1380-7

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:33159083 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.

Kramarz K et al. Nat Commun 2020 Nov 06;11(1):5643

PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24

PMID:15533439 - Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.

Stone M et al. J Mol Biol 2004 Nov 26;344(3):697-706

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22906049 - Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation.

Boehringer J et al. Biochem J 2012 Nov 15;448(1):55-65

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:10809753 - Analysis of a gene encoding Rpn10 of the fission yeast proteasome reveals that the polyubiquitin-binding site of this subunit is essential when Rpn12/Mts3 activity is compromised.

Wilkinson CR et al. J Biol Chem 2000 May 19;275(20):15182-92

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:11584278 - Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.

Wilkinson CR et al. Nat Cell Biol 2001 Oct;3(10):939-43

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:12553909 - Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.

Yen HC et al. Cell 2003 Jan 24;112(2):207-17

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:12615927 - Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins.

Seeger M et al. J Biol Chem 2003 May 09;278(19):16791-6

PMID:12783882 - Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly.

Yen HC et al. J Biol Chem 2003 Aug 15;278(33):30669-76

PMID:15120077 - The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes.

Hartmann-Petersen R et al. Curr Biol 2004 May 04;14(9):824-8

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:25306921 - Dss1 is a 26S proteasome ubiquitin receptor.

Paraskevopoulos K et al. Mol Cell 2014 Nov 06;56(3):453-461

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

Kamenz J et al. Mol Cell 2015 Nov 05;60(3):446-59

PMID:29856841 - Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast.

Yang Y et al. PLoS One 2018;13(6):e0198516

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20739285 - Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.

Riedinger C et al. J Biol Chem 2010 Oct 29;285(44):33992-4003

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:16149916 - Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Jossé L et al. Biochem J 2006 Jan 01;393(Pt 1):303-9

PMID:21098295 - Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Bohn S et al. Proc Natl Acad Sci U S A 2010 Dec 07;107(49):20992-7

PMID:28784663 - The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.

Seo HD et al. J Biol Chem 2017 Oct 13;292(41):17144-17155

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:38917328 - SUMO protease and proteasome recruitment at the nuclear periphery differently affect replication dynamics at arrested forks.

Schirmeisen K et al. Nucleic Acids Res 2024 Jun 25;

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;