protein coding gene - mst1 (SPAC637.12c) - histone acetyltransferase, KAT5 family Mst1

Gene summary

Standard name

mst1

Systematic ID

SPAC637.12c

Product

histone acetyltransferase, KAT5 family Mst1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

kat5

UniProt ID

O94446

ORFeome ID

21/21E06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4559101..4562829 reverse strand

Annotation

Protein features

Orthologs

• KAT5 (HGNC:5275) Homo sapiens
• mst1 (SJAG_02990) Schizosaccharomyces japonicus
• ESA1 (YOR244W) Saccharomyces cerevisiae

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.

Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:30992049 - The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.

Noguchi C et al. Epigenetics Chromatin 2019 Apr 16;12(1):24

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25972440 - Global regulation of heterochromatin spreading by Leo1.

Verrier L et al. Open Biol 2015 May;5(5)

PMID:20299455 - The fission yeast inhibitor of growth (ING) protein Png1p functions in response to DNA damage.

Chen JQ et al. J Biol Chem 2010 May 21;285(21):15786-93

PMID:16199868 - Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.

Gómez EB et al. Mol Cell Biol 2005 Oct;25(20):8887-903

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:19040720 - Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Shevchenko A et al. Genome Biol 2008;9(11):R167

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:19915592 - An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.

Kim HS et al. Nat Struct Mol Biol 2009 Dec;16(12):1286-93

PMID:29192674 - Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

Huang H et al. Cell Res 2018 Jan;28(1):111-125

PMID:15483052 - BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.

Minoda A et al. Mol Biol Cell 2005 Jan;16(1):316-27

PMID:35157728 - TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes.

Cohen A et al. PLoS Genet 2022 Feb;18(2):e1010061

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.

Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237

PMID:20299449 - A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.

Xhemalce B et al. Genes Dev 2010 Apr 01;24(7):647-52

PMID:22095079 - The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.

Garabedian MV et al. Genetics 2012 Feb;190(2):487-500

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:33723569 - Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double-strand break.

Li T et al. Genetics 2021 May 17;218(1)

PMID:23091701 - Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.

Nakamura T et al. Open Biol 2012 Sep;2(9):120117

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:25356590 - Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.

Mikheyeva IV et al. PLoS Genet 2014 Oct;10(10):e1004740

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52