protein coding gene - dut1 (SPAC644.05c) - deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene summary

Standard name

dut1

Systematic ID

SPAC644.05c

Product

deoxyuridine 5'-triphosphate nucleotidohydrolase

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P6Q5

ORFeome ID

03/03D10

Characterisation status

biological role inferred

Feature type

mRNA gene

Genomic location

chromosome I: 2678518..2679108 reverse strand

Annotation

Protein features

Orthologs

• DUT (HGNC:3078) Homo sapiens
• dut1 (SJAG_04487) Schizosaccharomyces japonicus
• DUT1 (YBR252W) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:41526646 - Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast.

Azadeh F et al. Sci Rep 2026 Jan 12;

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.

Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053