protein coding gene - dut1 (SPAC644.05c) - deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene summary

Standard name: dut1
Systematic ID: SPAC644.05c
Product: deoxyuridine 5'-triphosphate nucleotidohydrolase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P6Q5
ORFeome ID: 03/03D10
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 2678518..2679108 reverse strand

Annotation

Disease association

MONDO:0859288 - bone marrow failure and diabetes mellitus syndrome

References:

PB_REF:0000006

GO biological process

GO:0035863 - dITP catabolic process

References:

GO_REF:0000024

GO:0006226 - dUMP biosynthetic process

References:

GO_REF:0000033

GO:0046081 - dUTP catabolic process

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0035870 - dITP diphosphatase activity

References:

GO_REF:0000024

GO:0004170 - dUTP diphosphatase activity

References:

GO_REF:0000033

GO:0000287 - magnesium ion binding

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:21712547

MOD:01149 - sumoylated lysine

References:

PMID:26537787

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

PMID:36794724

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

dut1delta

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

PMID:23697806

Genotypes:

dut1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

dut1delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00692	dUTPase	dUTPase-like	PFAM
cd07557	trimeric_dUTPase	dUTPase_trimeric	CDD
G3DSA:2.70.40.10:FF:000004			FUNFAM
SSF51283	dUTPase-like	dUTPase-like_sf	SUPERFAMILY
G3DSA:2.70.40.10		dUTPase-like_sf	GENE3D
PTHR11241	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE	dUTPase	PANTHER
TIGR00576	dut	dUTPase	NCBIFAM
NF001862	PRK00601.1		NCBIFAM

Orthologs

DUT (HGNC:3078) Homo sapiens
dut1 (SJAG_04487) Schizosaccharomyces japonicus
DUT1 (YBR252W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.: Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.: Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.: Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.: Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.: Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;