protein coding gene - cdr1 (SPAC644.06c) - serine/threonine protein kinase (NIM1 family) Cdr1/Nim1

Gene summary

Standard name

cdr1

Systematic ID

SPAC644.06c

Product

serine/threonine protein kinase (NIM1 family) Cdr1/Nim1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

nim1, clo3

UniProt ID

P07334

ORFeome ID

36/36C10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2679468..2682407 reverse strand

Annotation

Protein features

Orthologs

• BRSK2 (HGNC:11405) Homo sapiens
• BRSK1 (HGNC:18994) Homo sapiens
• cdr1 (SJAG_04486) Schizosaccharomyces japonicus
• KCC4 (YCL024W) Saccharomyces cerevisiae
• GIN4 (YDR507C) Saccharomyces cerevisiae
• HSL1 (YKL101W) Saccharomyces cerevisiae

References / Literature

PMID:9928955 - Interaction between the fission yeast nim1/cdr1 protein kinase and a dynamin-related protein.

Pelloquin L et al. FEBS Lett 1999 Jan 22;443(1):71-4

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.

Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60

PMID:24508166 - Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Deng L et al. Curr Biol 2014 Feb 17;24(4):428-33

PMID:3453113 - The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis.

Russell P et al. Cell 1987 May 22;49(4):569-76

PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.

Chua G et al. Genetics 2002 Oct;162(2):689-703

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:9001228 - A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.

Matsumoto T Mol Cell Biol 1997 Feb;17(2):742-50

PMID:2245912 - stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.

Hudson JD et al. Genetics 1990 Oct;126(2):309-15

PMID:28539404 - Analysis of interphase node proteins in fission yeast by quantitative and superresolution fluorescence microscopy.

Akamatsu M et al. Mol Biol Cell 2017 Nov 07;28(23):3203-3214

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)

PMID:7937842 - Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.

Hannig G et al. Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10084-8

PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:22665807 - Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches.

Lu LX et al. Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9899-904

PMID:28924043 - Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.

Opalko HE et al. J Biol Chem 2017 Nov 10;292(45):18457-18468

PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.

Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:8515817 - Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase.

Parker LL et al. Nature 1993 Jun 24;363(6431):736-8

PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.

Jourdain I et al. PLoS One 2013;8(1):e54142

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:9135149 - Nif1, a novel mitotic inhibitor in Schizosaccharomyces pombe.

Wu L et al. EMBO J 1997 Mar 17;16(6):1342-50

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:34958661 - Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.

Opalko HE et al. J Cell Biol 2022 Feb 07;221(2)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:1549179 - The wee1 protein kinase is required for radiation-induced mitotic delay.

Rowley R et al. Nature 1992 Mar 26;356(6367):353-5

PMID:7681363 - Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer.

Coleman TR et al. Cell 1993 Mar 26;72(6):919-29

PMID:9843572 - The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.

Kanoh J et al. Mol Biol Cell 1998 Dec;9(12):3321-34

PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4933-41

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10835386 - Slm9, a novel nuclear protein involved in mitotic control in fission yeast.

Kanoh J et al. Genetics 2000 Jun;155(2):623-31

PMID:1464319 - Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4943-52

PMID:1588914 - Five novel elements involved in the regulation of mitosis in fission yeast.

Warbrick E et al. Mol Gen Genet 1992 Apr;232(3):440-6

PMID:2004705 - Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe.

Feilotter H et al. Genetics 1991 Feb;127(2):309-18

PMID:36574843 - Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2.

Berg RA et al. J Biol Chem 2023 Feb;299(2):102831

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:22684255 - The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

Grallert A et al. Nat Cell Biol 2012 Jun 10;14(7):738-45

PMID:11129054 - A novel member of the Swi6p family of fission yeast chromo domain-containing proteins associates with the centromere in vivo and affects chromosome segregation.

Halverson D et al. Mol Gen Genet 2000 Nov;264(4):492-505

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.

Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.

Martin SG et al. Nature 2009 Jun 11;459(7248):852-6

PMID:9034337 - Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

O'Connell MJ et al. EMBO J 1997 Feb 03;16(3):545-54

PMID:31644361 - A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

Opalko HE et al. Mol Biol Cell 2019 Dec 01;30(25):3015-3023

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:29514920 - Cell size-dependent regulation of Wee1 localization by Cdr2 cortical nodes.

Allard CAH et al. J Cell Biol 2018 May 07;217(5):1589-1599

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:16816416 - Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1.

Calonge TM et al. Genetics 2006 Sep;174(1):113-23

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:3448096 - Schizosaccharomyces pombe mutants affected in their division response to starvation.

Young PG et al. J Cell Sci 1987 Oct;88 ( Pt 3):295-304

GO_REF:0000051 - S. pombe keyword mapping

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:8515818 - Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase.

Wu L et al. Nature 1993 Jun 24;363(6431):738-41

PMID:2406029 - Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.

Enoch T et al. Cell 1990 Feb 23;60(4):665-73

PMID:26071525 - Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2.

Guzmán-Vendrell M et al. J Cell Sci 2015 Aug 01;128(15):2842-53