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protein coding gene - pkp1 (SPAC644.11c) - mitochondrial pyruvate dehydrogenase (lipoamide) kinase Pkp1

Gene summary

Standard name
pkp1
Systematic ID
SPAC644.11c
Product
mitochondrial pyruvate dehydrogenase (lipoamide) kinase Pkp1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6P9
ORFeome ID
24/24C08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2691298..2693759 reverse strand

Annotation

Disease association

MONDO:0010479 - Charcot-Marie-Tooth disease X-linked dominant 6

References:

GO biological process

GO:0006086 - pyruvate decarboxylation to acetyl-CoA

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GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity

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Modification

MOD:00890 - phosphorylated L-histidine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF02518HATPase_cHATPase_domPfam
PF10436BCDHK_Adom3BCDHK/PDK_NPfam
cd16929HATPase_PDK-likeCDD
PS50109HIS_KINHis_kinase_domPROSITE profiles
SM00387HATPase_cHATPase_domSMART
PR00344BCTRLSENSORSig_transdc_His_kin-like_CPRINTS
G3DSA:1.20.140.20AK/P_DHK_N_sfCATH-Gene3D
G3DSA:3.30.565.10HATPase_C_sfCATH-Gene3D
SSF55874HATPase_C_sfSUPERFAMILY
SSF69012AK/P_DHK_N_sfSUPERFAMILY
PTHR11947BCKD/PDKPANTHER

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs