protein coding gene - rad51 (SPAC644.14c) - RecA family recombinase Rad51/Rhp51

Gene summary

Standard name

rad51

Systematic ID

SPAC644.14c

Product

RecA family recombinase Rad51/Rhp51

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rhp51, loh4

UniProt ID

P36601

ORFeome ID

17/17B11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2698110..2700269 reverse strand

Annotation

Protein features

Orthologs

• RAD51 (HGNC:9817) Homo sapiens
• rad51 (SJAG_01410) Schizosaccharomyces japonicus
• RAD51 (YER095W) Saccharomyces cerevisiae

References / Literature

PMID:15359282 - Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

Xhemalce B et al. EMBO J 2004 Oct 01;23(19):3844-53

PMID:10430583 - A new recombinational DNA repair gene from Schizosaccharomyces pombe with homology to Escherichia coli RecA.

Khasanov FK et al. Genetics 1999 Aug;152(4):1557-72

PMID:30297419 - Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.

Lu CH et al. Proc Natl Acad Sci U S A 2018 Oct 23;115(43):E10059-E10068

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:29323270 - Two three-strand intermediates are processed during Rad51-driven DNA strand exchange.

Ito K et al. Nat Struct Mol Biol 2018 Jan;25(1):29-36

PMID:37237082 - Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere.

Mongia P et al. Commun Biol 2023 May 26;6(1):551

PMID:16921379 - The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.

Haruta N et al. Nat Struct Mol Biol 2006 Sep;13(9):823-30

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:26652183 - Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.

Callegari AJ et al. Cell Cycle 2016;15(2):261-73

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:12930956 - Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.

Kibe T et al. Nucleic Acids Res 2003 Sep 01;31(17):5054-63

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:26041456 - RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.

Audry J et al. EMBO J 2015 Jul 14;34(14):1942-58

PMID:12419233 - Increased recombination intermediates and homologous integration hot spots at DNA replication origins.

Segurado M et al. Mol Cell 2002 Oct;10(4):907-16

PMID:16912194 - Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin.

Herrero AB et al. Cancer Res 2006 Aug 15;66(16):8155-62

PMID:23297345 - Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.

Nanbu T et al. Mol Cell Biol 2013 Mar;33(6):1175-87

PMID:28475874 - Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.

Ait Saada A et al. Mol Cell 2017 May 04;66(3):398-410.e4

PMID:29215009 - The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.

Teixeira-Silva A et al. Nat Commun 2017 Dec 07;8(1):1982

PMID:15802523 - A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.

Hope JC et al. Genetics 2005 Jun;170(2):519-31

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:15805465 - Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.

Kai M et al. Genes Dev 2005 Apr 15;19(8):919-32

PMID:22927644 - Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Sánchez A et al. Mol Cell Biol 2012 Nov;32(21):4445-54

PMID:16135799 - Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.

Morishita T et al. Mol Cell Biol 2005 Sep;25(18):8074-83

PB_REF:0000003 - Disease Association Curation

PMID:19205745 - Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.

Yasuhira S Mol Genet Genomics 2009 May;281(5):497-509

PMID:20231270 - Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Selvanathan SP et al. J Biol Chem 2010 May 07;285(19):14122-33

PMID:17936710 - Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Limbo O et al. Mol Cell 2007 Oct 12;28(1):134-46

PMID:21444718 - DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Prudden J et al. Mol Cell Biol 2011 Jun;31(11):2299-310

PMID:21852501 - Aneuploidy drives genomic instability in yeast.

Sheltzer JM et al. Science 2011 Aug 19;333(6045):1026-30

PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.

Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557

PMID:18378696 - Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.

Akamatsu Y et al. Mol Cell Biol 2008 Jun;28(11):3639-51

PMID:11560889 - Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.

Tsutsui Y et al. Genetics 2001 Sep;159(1):91-105

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20065069 - The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.

Willis N et al. Genetics 2010 Apr;184(4):887-97

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:11073995 - Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe.

Shim YS et al. Mol Cell Biol 2000 Dec;20(23):8958-68

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:24741789 - Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.

Stanescu RS et al. Rev Med Chir Soc Med Nat Iasi 2014;118(1):133-40

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.

Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57

PMID:22064477 - The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM et al. Mol Cell Biol 2012 Jan;32(2):276-87

PMID:15336631 - Identification and characterization of the rlp1+, the novel Rad51 paralog in the fission yeast Schizosaccharomyces pombe.

Khasanov FK et al. DNA Repair (Amst) 2004 Oct 05;3(10):1363-74

PMID:33511417 - Repression of a large number of genes requires interplay between homologous recombination and HIRA.

Misova I et al. Nucleic Acids Res 2021 Feb 26;49(4):1914-1934

PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.

Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)

PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73

PMID:24875629 - Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Ding L et al. G3 (Bethesda) 2014 May 28;4(8):1373-84

PMID:15486206 - DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.

Doe CL et al. Nucleic Acids Res 2004;32(18):5570-81

PMID:8358431 - Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.

Shinohara A et al. Nat Genet 1993 Jul;4(3):239-43

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:22405003 - Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.

Kuwabara N et al. Structure 2012 Mar 07;20(3):440-9

PMID:8834792 - Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity.

Muris DF et al. J Cell Sci 1996 Jan;109 ( Pt 1):73-81

PMID:34292936 - Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.

Su J et al. PLoS Genet 2021 Jul;17(7):e1009671

PMID:27398807 - Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Nie M et al. PLoS Genet 2016 Jul;12(7):e1006165

PMID:12019258 - A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe.

Farah JA et al. Genetics 2002 May;161(1):461-8

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:26957021 - The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks.

Osman F et al. Sci Rep 2016 Mar 09;6:22837

PMID:11884628 - Differential expression and requirements for Schizosaccharomyces pombe RAD52 homologs in DNA repair and recombination.

van den Bosch M et al. Nucleic Acids Res 2002 Mar 15;30(6):1316-24

PMID:23093942 - Recovery of arrested replication forks by homologous recombination is error-prone.

Iraqui I et al. PLoS Genet 2012;8(10):e1002976

PMID:12509234 - Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.

Oakley TJ et al. DNA Repair (Amst) 2002 Jun 21;1(6):463-82

PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.

Roseaulin L et al. EMBO J 2008 May 07;27(9):1378-87

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:8233794 - Cloning the RAD51 homologue of Schizosaccharomyces pombe.

Muris DF et al. Nucleic Acids Res 1993 Sep 25;21(19):4586-91

PMID:15331764 - Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Pebernard S et al. Mol Biol Cell 2004 Nov;15(11):4866-76

PMID:12589755 - The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Kanoh J et al. J Mol Biol 2003 Feb 28;326(4):1081-94

PMID:17515930 - Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

Kai M et al. Nat Cell Biol 2007 Jun;9(6):691-7

PMID:15899844 - Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments.

Sauvageau S et al. Mol Cell Biol 2005 Jun;25(11):4377-87

PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.

Young JA et al. Genetics 2004 Jun;167(2):593-605

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:22252817 - A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Fang Y et al. Antimicrob Agents Chemother 2012 Apr;56(4):1949-59

GO_REF:0000051 - S. pombe keyword mapping

PMID:23118915 - Stress activated protein kinase pathway modulates homologous recombination in fission yeast.

Bellini A et al. PLoS One 2012;7(10):e47987

PMID:18923422 - Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe.

Nakamura K et al. EMBO J 2008 Nov 19;27(22):3036-46

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:23516381 - DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.

Norman-Axelsson U et al. PLoS Genet 2013;9(3):e1003371

PMID:28922417 - Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

Sanchez A et al. PLoS Genet 2017 Sep;13(9):e1007013

PMID:29167439 - Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.

Maestroni L et al. Nat Commun 2017 Nov 22;8(1):1684

PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24

PMID:16532353 - Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.

Lorenz A et al. Chromosoma 2006 Aug;115(4):330-40

PMID:11719193 - Mus81-Eme1 are essential components of a Holliday junction resolvase.

Boddy MN et al. Cell 2001 Nov 16;107(4):537-48

PMID:14765108 - Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.

den Elzen NR et al. EMBO J 2004 Feb 25;23(4):908-18

PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM et al. EMBO J 2019 Apr 01;38(7)

PMID:26305931 - Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Webb CJ et al. Proc Natl Acad Sci U S A 2015 Sep 08;112(36):11312-7

PMID:33159083 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.

Kramarz K et al. Nat Commun 2020 Nov 06;11(1):5643

PMID:37330173 - Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.

Liang P et al. J Biol Chem 2023 Aug;299(8):104929

PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S et al. Sci Adv 2018 May;4(5):eaar2740

PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502

PMID:18769921 - Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.

Khasanov FK et al. Curr Genet 2008 Oct;54(4):197-211

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:39789818 - SRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe.

Lu G et al. Genes Cells 2025 Jan;30(1):e13192

PMID:16080597 - [The dds20+ gene controls a novel Rad51Sp-dependent pathway of recombinational repair in Schizosaccharomyces pombe].

Salakhova AF et al. Genetika 2005 Jun;41(6):736-45

PMID:11726502 - Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.

Hartsuiker E et al. EMBO J 2001 Dec 03;20(23):6660-71

PMID:8610150 - Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.

Kovalenko OV et al. Proc Natl Acad Sci U S A 1996 Apr 02;93(7):2958-63

PMID:12724426 - Role for the fission yeast RecQ helicase in DNA repair in G2.

Laursen LV et al. Mol Cell Biol 2003 May;23(10):3692-705

PMID:14668362 - Five RecA-like proteins of Schizosaccharomyces pombe are involved in meiotic recombination.

Grishchuk AL et al. Genetics 2003 Nov;165(3):1031-43

PMID:21183410 - Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R et al. DNA Repair (Amst) 2011 Mar 07;10(3):283-95

PMID:18675827 - The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).

Jansson K et al. Mutat Res 2008 Sep 26;644(1-2):48-55

PMID:17304215 - Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.

Akamatsu Y et al. EMBO J 2007 Mar 07;26(5):1352-62

PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.

Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60

PMID:17762865 - SUMO-targeted ubiquitin ligases in genome stability.

Prudden J et al. EMBO J 2007 Sep 19;26(18):4089-101

PMID:27697832 - Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.

Onaka AT et al. Nucleic Acids Res 2016 Dec 15;44(22):10744-10757

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31149897 - The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast.

Tamang S et al. Elife 2019 May 31;8

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15329725 - Separase-mediated cleavage of cohesin at interphase is required for DNA repair.

Nagao K et al. Nature 2004 Aug 26;430(7003):1044-8

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.

Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208

PMID:22313747 - A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.

Ukimori S et al. Biosci Biotechnol Biochem 2012;76(2):264-9

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:17178839 - Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.

Kearsey SE et al. Mol Cell Biol 2007 Mar;27(5):1558-67

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39174851 - CDK phosphorylation of Sfr1 downregulates Rad51 function in late-meiotic homolog invasions.

Palacios-Blanco I et al. EMBO J 2024 Aug 22;

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PMID:11104907 - Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe.

van den Bosch M et al. Mutat Res 2001 Jan 05;461(4):311-23

PMID:18180284 - Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.

Bailis JM et al. Mol Cell Biol 2008 Mar;28(5):1724-38

PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14

PMID:27738016 - RNA interference is essential for cellular quiescence.

Roche B et al. Science 2016 Nov 11;354(6313)

PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30

PMID:15915339 - Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.

Tsutsui Y et al. Curr Genet 2005 Jul;48(1):34-43

PMID:25165823 - Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Tsutsui Y et al. PLoS Genet 2014 Aug;10(8):e1004542

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:25313826 - The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.

Pietrobon V et al. PLoS Biol 2014 Oct;12(10):e1001968

PMID:26891792 - Calcium modulation of doxorubicin cytotoxicity in yeast and human cells.

Nguyen TT et al. Genes Cells 2016 Mar;21(3):226-40

PMID:28977643 - Regulation of mitotic recombination between DNA repeats in centromeres.

Zafar F et al. Nucleic Acids Res 2017 Nov 02;45(19):11222-11235

PMID:24909977 - A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.

Pai CC et al. Nat Commun 2014 Jun 09;5:4091

PMID:15643072 - Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.

Williams DR et al. Eukaryot Cell 2005 Jan;4(1):166-77

PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.

Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302

PMID:18416603 - Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators.

Kurokawa Y et al. PLoS Biol 2008 Apr 15;6(4):e88

PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Tay Z et al. PLoS One 2013;8(1):e55041

PMID:19363481 - Molecular mimicry of SUMO promotes DNA repair.

Prudden J et al. Nat Struct Mol Biol 2009 May;16(5):509-16

PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.

Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658

PMID:28334931 - Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.

Manjón E et al. Nucleic Acids Res 2017 May 19;45(9):5269-5284

PMID:9870697 - Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Mol Gen Genet 1998 Nov;260(4):319-34

PMID:21408210 - SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Heideker J et al. PLoS Genet 2011 Mar;7(3):e1001320

PMID:33493431 - A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors.

Afshar N et al. Elife 2021 Jan 25;10

PMID:15367656 - Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E et al. Mol Cell Biol 2004 Oct;24(19):8342-55

PMID:11452021 - Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.

Wang SW et al. Nucleic Acids Res 2001 Jul 15;29(14):2963-72

PMID:19185548 - The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

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