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protein coding gene - bet3 (SPAC644.18c) - TRAPP I, II and III complex RabGEF subunit Bet3

Gene summary

Standard name
bet3
Systematic ID
SPAC644.18c
Product
TRAPP I, II and III complex RabGEF subunit Bet3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6P5
ORFeome ID
08/08B12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2704213..2705627 reverse strand

Annotation

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0006891 - intra-Golgi vesicle-mediated transport

References:

GO:0016236 - macroautophagy

References:

GO cellular component

GO:0033106 - cis-Golgi network membrane

References:

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:1990070 - TRAPPI protein complex

References:

GO:1990071 - TRAPPII protein complex

References:

GO:1990072 - TRAPPIII protein complex

References:

GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

References:

Modification

MOD:00115 - S-palmitoyl-L-cysteine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04051TRAPPTRAPP_componentPfam
cd14942TRAPPC3_bet3Bet3CDD
G3DSA:3.30.1380.20:FF:000001CATH-FunFam
G3DSA:3.30.1380.20CATH-Gene3D
SSF111126NO_sig/Golgi_transp_ligand-bdSUPERFAMILY
PTHR13048Bet3PANTHER
PIRSF018293TRAPP_I_complex_Bet3Bet3PIRSF

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83